Wu Hebi, Chen Shugeng, Jia Jie
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
Institute for Translational Brain Research, Fudan University, Shanghai 200030, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Jun 25;42(3):480-487. doi: 10.7507/1001-5515.202404015.
Stroke causes abnormality of brain physiological function and limb motor function. Brain-computer interface (BCI) connects the patient's active consciousness to an external device, so as to enhance limb motor function. Previous studies have preliminarily confirmed the efficacy of BCI rehabilitation training in improving upper limb motor function after stroke, but the brain mechanism behind it is still unclear. This paper aims to review on the brain mechanism of upper limb motor dysfunction in stroke patients and the improvement of brain function in those receiving BCI training, aiming to further explore the brain mechanism of BCI in promoting the rehabilitation of upper limb motor function after stroke. The results of this study show that in the fields of imaging and electrophysiology, abnormal activity and connectivity have been found in stroke patients. And BCI training for stroke patients can improve their upper limb motor function by increasing the activity and connectivity of one hemisphere of the brain and restoring the balance between the bilateral hemispheres of the brain. This article summarizes the brain mechanism of BCI in promoting the rehabilitation of upper limb motor function in stroke in both imaging and electrophysiology, and provides a reference for the clinical application and scientific research of BCI in stroke rehabilitation in the future.
中风会导致大脑生理功能和肢体运动功能异常。脑机接口（BCI）将患者的主动意识与外部设备相连，以增强肢体运动功能。以往研究初步证实了BCI康复训练对改善中风后上肢运动功能的疗效，但其背后的脑机制仍不清楚。本文旨在综述中风患者上肢运动功能障碍的脑机制以及接受BCI训练患者的脑功能改善情况，以期进一步探究BCI促进中风后上肢运动功能康复的脑机制。本研究结果表明，在成像和电生理领域，已发现中风患者存在异常活动和连接性。对中风患者进行BCI训练可通过增加大脑一个半球的活动和连接性以及恢复大脑双侧半球之间的平衡来改善其上肢运动功能。本文从成像和电生理两方面总结了BCI促进中风患者上肢运动功能康复的脑机制，为未来BCI在中风康复中的临床应用和科学研究提供参考。
