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祖细胞疗法治疗获得性儿科神经系统损伤：外伤性脑损伤和获得性感觉神经性听力损失。

Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss.

机构信息

Advent Health for Children, Orlando, Florida, USA.

Department of Neurological Surgery, University of Central Florida College of Medicine, Orlando, Florida, USA.

出版信息

Stem Cells Transl Med. 2021 Feb;10(2):164-180. doi: 10.1002/sctm.20-0026. Epub 2020 Oct 9.

DOI:10.1002/sctm.20-0026
PMID:33034162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7848325/
Abstract

While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatment with varieties of adult, multipotent stem cells can improve outcomes in patients with neurological conditions such as traumatic brain injury and hearing loss without directly replacing damaged or lost cells. As the immune system plays a central role in injury response and tissue repair, we here suggest that multipotent stem cell therapies achieve therapeutic effect by altering the immune response to injury, thereby limiting damage due to inflammation and possibly promoting repair. These findings argue for a broader understanding of the mechanisms by which cell therapies can benefit patients.

摘要

虽然细胞疗法在替代受损细胞和修复受损组织方面具有显著的潜力，但细胞替代并不是这些疗法实现治疗效果的唯一手段。例如，最近的出版物表明，用各种成年多能干细胞进行治疗可以改善创伤性脑损伤和听力损失等神经疾病患者的预后，而无需直接替代受损或丢失的细胞。由于免疫系统在损伤反应和组织修复中起着核心作用，我们在此提出，多能干细胞疗法通过改变对损伤的免疫反应来实现治疗效果，从而限制炎症引起的损伤，并可能促进修复。这些发现为更广泛地理解细胞疗法如何使患者受益的机制提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/46b6dcdbc633/SCT3-10-164-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/daf09310a3a5/SCT3-10-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/bf9e19937c59/SCT3-10-164-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/28625491ce99/SCT3-10-164-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/46b6dcdbc633/SCT3-10-164-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/daf09310a3a5/SCT3-10-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/bf9e19937c59/SCT3-10-164-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/28625491ce99/SCT3-10-164-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea10/7848325/46b6dcdbc633/SCT3-10-164-g004.jpg

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本文引用的文献

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Exp Neurol. 2020 Jul;329:113310. doi: 10.1016/j.expneurol.2020.113310. Epub 2020 Apr 11.
2
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles.靶向和穿越血脑屏障的细胞外囊泡。
Cells. 2020 Apr 1;9(4):851. doi: 10.3390/cells9040851.
3
Progressive Histopathological Damage Occurring Up to One Year after Experimental Traumatic Brain Injury Is Associated with Cognitive Decline and Depression-Like Behavior.
新冠疫情期间伊朗北部儿童创伤性脑损伤：一份国家报告
Int J Burns Trauma. 2022 Aug 15;12(4):175-179. eCollection 2022.
4
The audiogram: Detection of pure-tone stimuli in ototoxicity monitoring and assessments of investigational medicines for the inner ear.听力图：耳毒性监测中的纯音刺激检测以及内耳研究药物的评估。
J Acoust Soc Am. 2022 Jul;152(1):470. doi: 10.1121/10.0011739.
实验性创伤性脑损伤后长达一年的进行性组织病理学损伤与认知功能下降和抑郁样行为有关。
J Neurotrauma. 2020 Jun 1;37(11):1331-1341. doi: 10.1089/neu.2019.6510. Epub 2020 Feb 5.
4
Imaging biomarkers of posttraumatic epileptogenesis.创伤后癫痫发生的影像学生物标志物。
Epilepsia. 2019 Nov;60(11):2151-2162. doi: 10.1111/epi.16357. Epub 2019 Oct 8.
5
Human mesenchymal stem cells-derived conditioned medium inhibits hypoxia-induced death of neonatal porcine islets by inducing autophagy.人骨髓间充质干细胞条件培养液通过诱导自噬抑制低氧诱导的新生猪胰岛细胞死亡。
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7
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Semin Cell Dev Biol. 2019 Oct;94:152-163. doi: 10.1016/j.semcdb.2019.06.001. Epub 2019 Jun 22.