Reed D, Yano K, Kagan A
Am J Med. 1986 May;80(5):871-8. doi: 10.1016/0002-9343(86)90631-5.
A group of 2,122 healthy men in the Honolulu Heart Program who participated in the Cooperative Lipoprotein Phenotyping Study, 1970 to 1972, were followed for 10 years by repeated examinations and surveillance of hospital discharge and mortality records in order to diagnose new cases of coronary heart disease, stroke, cancer, and other deaths. Total cholesterol and low-density lipoprotein cholesterol were significantly associated with all clinical types of coronary heart disease in multivariate analyses, whereas high-density lipoprotein cholesterol was inversely associated with nonfatal myocardial infarction and total coronary heart disease, but not with fatal coronary heart disease nor angina. Triglyceride and very-low-density lipoprotein cholesterol were associated with total coronary heart disease by univariate but not multivariate analysis. None of the other specific chronic diseases were significantly associated with any lipid or lipoprotein, although there were trends of inverse associations of all noncardiovascular disease with total cholesterol and low-density lipoprotein cholesterol. Thus, for total disease (coronary heart disease, stroke, cancer, and other deaths), the optimal range for lowest disease incidence was about 200 to 220 mg/dl for total cholesterol and 120 to 140 mg/dl for low-density lipoprotein cholesterol. A strong inverse pattern of total disease with high-density lipoprotein cholesterol indicated that the highest levels were the optimal levels.
在1970年至1972年参与合作脂蛋白表型研究的檀香山心脏项目中，一组2122名健康男性接受了为期10年的随访，通过反复检查以及对医院出院和死亡记录的监测，以诊断冠心病、中风、癌症的新病例和其他死亡情况。在多变量分析中，总胆固醇和低密度脂蛋白胆固醇与冠心病的所有临床类型均显著相关，而高密度脂蛋白胆固醇与非致命性心肌梗死和总冠心病呈负相关，但与致命性冠心病和心绞痛无关。甘油三酯和极低密度脂蛋白胆固醇在单变量分析中与总冠心病相关，但在多变量分析中不相关。其他特定慢性病均与任何脂质或脂蛋白无显著关联，尽管所有非心血管疾病与总胆固醇和低密度脂蛋白胆固醇呈负相关趋势。因此，对于所有疾病（冠心病、中风、癌症和其他死亡），总胆固醇的最低疾病发病率最佳范围约为200至220mg/dl，低密度脂蛋白胆固醇为120至140mg/dl。总疾病与高密度脂蛋白胆固醇呈强烈的负相关模式，表明最高水平为最佳水平。
