Cao Dan, Zhang Zongxin
Department of Hematology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.
Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.
Front Oncol. 2023 Mar 30;13:1169749. doi: 10.3389/fonc.2023.1169749. eCollection 2023.
Previous studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects DLBCL and its function in terms of prognosis.
The Web of Science, PubMed, Embase, and Cochrane Library databases were thoroughly searched until January 18, 2023. We calculated combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the relationship between the GNRI and survival outcomes of patients with DLBCL.
This meta-analysis included seven articles involving 2,353 cases. A lower level of GNRI predicted dismal overall survival (HR=1.40, 95% CI=1.25-1.56, p<0.001) and inferior progression-free survival (HR=1.46, 95% CI=1.19-1.80, p<0.001) of DLBCL patients. Moreover, a low GNRI was significantly related to Eastern Cooperative Oncology Group Performance Status ≥2 (odds ratio [OR]=4.55, 95% CI=2.75-7.54, p<0.001), Ann Arbor stage III-IV (OR=2.91, 95% CI=2.38-3.57, p<0.001), B symptoms (OR=3.51, 95% CI=2.34-5.29, p<0.001), and extranodal disease (OR=2.90, 95% CI=2.32-3.63, p<0.001).
A lower GNRI level predicted poorer short- and long-term prognosis in patients with DLBCL. A low GNRI was correlated with clinical factors of disease progression in DLBCL patients.
既往研究探讨了老年营养风险指数（GNRI）与弥漫性大B细胞淋巴瘤（DLBCL）患者生存结局之间的关系，但结果并不一致。因此，本荟萃分析旨在研究GNRI如何影响DLBCL及其在预后方面的作用。
全面检索了Web of Science、PubMed、Embase和Cochrane图书馆数据库，检索截至2023年1月18日的文献。我们计算了合并风险比（HR）和95%置信区间（CI），以评估GNRI与DLBCL患者生存结局之间的关系。
本荟萃分析纳入了7篇文章，共2353例患者。较低的GNRI水平预示着DLBCL患者的总生存期较差（HR=1.40，95%CI=1.25-1.56，p<0.001）和无进展生存期较差（HR=1.46，95%CI=1.19-1.80，p<0.001）。此外，低GNRI与东部肿瘤协作组体能状态≥2显著相关（优势比[OR]=4.55，95%CI=2.75-7.54，p<0.001）、Ann Arbor分期III-IV期（OR=2.91，95%CI=2.38-3.57，p<0.001）、B症状（OR=3.51, 95%CI=2.34-5.29, p<0.001）和结外病变（OR=2.90, 95%CI=2.32-3.63, p<0.001）。
较低的GNRI水平预示着DLBCL患者的短期和长期预后较差。低GNRI与DLBCL患者疾病进展的临床因素相关。
