The Second Affiliated Hospital of Nanchang University, 1 Min De Road, Nanchang, 330006, Jiangxi, China.
School of Nursing, Nanchang University, 461 Ba Yi Road, Nanchang, 330006, Jiangxi, China.
Clin Transl Oncol. 2024 Feb;26(2):515-523. doi: 10.1007/s12094-023-03271-w. Epub 2023 Jul 12.
Geriatric nutritional risk index (GNRI) on the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) remains unclear. The purpose of this meta-analysis was to discuss the value of the GNRI in evaluating long-term outcomes in DLBCL.
We systematically and roundly retrieved PubMed, Cochrane Library, Embase, Scopus and Web of Science electronic databases from inception of the databases to March 20, 2023. At the same time, we calculated the pool hazard ratios (HRs) with their 95% confidence interval (CI) for overall survival and progression-free survival to assess the effect of GNRI on the prognosis of DLBCL patients.
In our primary meta-analysis, 7 trials with a total of 2448 patients were enrolled. Results showed that lower level of GNRI was related to poorer overall survival (HR = 1.78, 95% CI 1.27, 2.50, p < 0.01) and worse progression-free survival (HR = 2.31, 95% CI 1.71, 3.13, p < 0.01) in DLBCL patients.
The results of our meta-analysis indicate that a lower GNRI significantly associated with poorer prognosis for DLBCL. It is believed that GNRI was a promisingly predictive indicator of survival outcomes in DLBCL patients. However, large multicenter prospective studies are necessary to verify the results.
老年营养风险指数（GNRI）对弥漫性大 B 细胞淋巴瘤（DLBCL）患者预后的影响尚不清楚。本荟萃分析的目的是探讨 GNRI 评估 DLBCL 患者长期结局的价值。
我们系统、全面地检索了 PubMed、Cochrane 图书馆、Embase、Scopus 和 Web of Science 电子数据库，检索时间从数据库建立到 2023 年 3 月 20 日。同时，我们计算了总生存和无进展生存的汇总风险比（HRs）及其 95%置信区间（CI），以评估 GNRI 对 DLBCL 患者预后的影响。
在我们的主要荟萃分析中，共纳入了 7 项试验，总计 2448 例患者。结果表明，GNRI 水平较低与总生存较差（HR=1.78，95%CI 1.27，2.50，p<0.01）和无进展生存较差（HR=2.31，95%CI 1.71，3.13，p<0.01）相关。
荟萃分析的结果表明，较低的 GNRI 与 DLBCL 患者预后较差显著相关。相信 GNRI 是 DLBCL 患者生存结局的一个很有前途的预测指标。然而，需要进行大型多中心前瞻性研究来验证这些结果。
