Kumar Visesh, Rani Priti, Rai Neha, Kumar Subhash, Mahto Mala
Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India.
Department of Radiodiagnosis, All India Institute of Medical Sciences , Patna, Bihar, India.
J Lab Physicians. 2022 Jul 26;15(1):162-165. doi: 10.1055/s-0042-1750080. eCollection 2023 Mar.
Laboratory investigations for any suspected case of solitary plasmacytoma of bone include routine biochemical and hematological investigations along with β2-microglobulin, electrophoresis of serum protein and/or 24-hour urine protein, serum protein immunofixation (IFE), and nephelometric quantification of total immunoglobulin isotype and serum free light chain levels. Bone marrow aspirate and trephine biopsy are mandatory to confirm the absence of clonal plasma cells (for solitary plasmacytoma) or the presence of less than 10% clonal cells (solitary plasmacytoma with minimal bone marrow involvement). Imaging studies such as X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT should be used to complement laboratory tests in diagnosis, staging, and defining the local extent of the plasmacytoma. However, guidelines regarding choice of technique for the detection of M band when monitoring a follow-up case of operated plasmacytoma are still not clear. Through this case study, we try to highlight the role of IFE in a follow-up case of operated solitary plasmacytoma of the bone.
对于任何疑似骨孤立性浆细胞瘤的病例，实验室检查包括常规生化和血液学检查，以及β2微球蛋白、血清蛋白电泳和/或24小时尿蛋白、血清蛋白免疫固定电泳（IFE），以及总免疫球蛋白同种型和血清游离轻链水平的散射比浊定量。骨髓穿刺和活检对于确认是否不存在克隆性浆细胞（针对孤立性浆细胞瘤）或是否存在少于10%的克隆性细胞（骨髓受累最小的孤立性浆细胞瘤）是必不可少的。诸如X射线、计算机断层扫描（CT）、磁共振成像和正电子发射断层扫描/CT等影像学检查应用于辅助实验室检查进行诊断、分期以及确定浆细胞瘤的局部范围。然而，在监测骨孤立性浆细胞瘤手术病例的随访时，关于M带检测技术选择的指南仍不明确。通过本病例研究，我们试图强调IFE在骨孤立性浆细胞瘤手术随访病例中的作用。
