Venugopal Sathish, Dhanoa Ravneet K, Selvamani Tharun Yadhav, Shoukrie Shoukrie I, Zahra Anam, Malla Jyothirmai, Selvaraj Ramaneshwar, Hamouda Ranim K, Mohammed Lubna
Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2023 Mar 13;15(3):e36079. doi: 10.7759/cureus.36079. eCollection 2023 Mar.
Diabetes is associated with different types of cancers of which hepatocellular carcinoma (HCC) is one among them. In a study comparing patients with diabetes to those who do not have diabetes, it was evident that the risk of HCC is found to increase two-fold in diabetic than that in non-diabetic patients. It is clear that carcinogenesis is advanced due to diabetes in the liver by a variety of mechanisms. We searched PubMed and Google Scholar for articles from 2010 to 2021 that have an association between diabetes, nonalcoholic fatty liver disease (NAFLD), and HCC. For the development of HCC, diabetes is likely related at both the molecular and epidemiological levels. Both diabetes mellitus and hepatic malignancy have the worst impact on mankind socioeconomically. There is a significant relationship between diabetes and HCC independent of alcohol consumption and viral hepatitis. It is noteworthy that not only the elderly but also people of all age groups should monitor their hemoglobin A1C levels. Diet restriction and lifestyle modification can reduce the risk of complications like HCC; the increased physical activity itself can have a major influence on health and can manage comorbidities like diabetes, NAFLD, and HCC.
糖尿病与不同类型的癌症相关，肝细胞癌（HCC）是其中之一。在一项将糖尿病患者与非糖尿病患者进行比较的研究中，明显发现糖尿病患者患HCC的风险是非糖尿病患者的两倍。显然，糖尿病通过多种机制促进了肝脏的致癌作用。我们在PubMed和谷歌学术上搜索了2010年至2021年期间有关糖尿病、非酒精性脂肪性肝病（NAFLD）和HCC之间关联的文章。对于HCC的发生发展，糖尿病可能在分子和流行病学层面都存在关联。糖尿病和肝脏恶性肿瘤对人类社会经济都有最严重的影响。糖尿病与HCC之间存在显著关联，且与饮酒和病毒性肝炎无关。值得注意的是，不仅老年人，所有年龄段的人都应监测其糖化血红蛋白水平。饮食限制和生活方式改变可以降低HCC等并发症的风险；增加体育活动本身就能对健康产生重大影响，并能控制糖尿病、NAFLD和HCC等合并症。
