吸烟与胰腺癌肺转移无关。
Smoking is Not Associated with Lung Metastasis in Pancreatic Cancer.
机构信息
Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Cancer Invest. 2023 May;41(5):487-490. doi: 10.1080/07357907.2023.2203747. Epub 2023 May 23.
Smoking is a risk factor for pulmonary metastasis in various malignancies. We investigated this association for pancreatic ductal adenocarcinoma (PDAC). We conducted a retrospective 1:2 case-control study of consecutive patients who underwent PDAC resection (2011-2021). Cases ultimately developed lung metastases and controls did not. Of 744 patients we identified 53 cases and 106 matched controls. Twenty-five (47%) cases and 50 (47%) matched controls had a history of smoking ( = 1.0). This indicates that smoking is not associated with increased risk of pulmonary metastasis in resectable PDAC. Further research is needed to elucidate tumor and parenchymal factors influencing metastatic site.
吸烟是多种恶性肿瘤肺转移的危险因素。我们研究了这种关联在胰腺导管腺癌（PDAC）中的作用。我们对连续接受 PDAC 切除术的患者（2011-2021 年）进行了回顾性 1:2 病例对照研究。病例最终发生肺转移，而对照没有。在 744 名患者中，我们确定了 53 例病例和 106 例匹配对照。25 例（47%）病例和 50 例（47%）匹配对照有吸烟史（ = 1.0）。这表明，在可切除的 PDAC 中，吸烟与肺转移风险增加无关。需要进一步研究阐明影响转移部位的肿瘤和实质因素。
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