Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington.
Department of Genome Sciences, University of Washington, Seattle, Washington.
Blood Cancer Discov. 2023 Jul 5;4(4):252-253. doi: 10.1158/2643-3230.BCD-23-0041.
In this issue of Blood Cancer Discovery, Kotini and colleagues present a strategy for large-scale reprogramming of primary human acute myeloid leukemias (AML) to induced pluripotent stem cell (iPSC). They show that the hematopoietic differentiation of AML iPSCs gives rise to transplantable leukemias with remarkable molecular similarity to the original patients' AML, providing new models and insights into the disease. See related article by Kotini et al., p. 318 (7) .
在本期《Blood Cancer Discovery》中，Kotini 及其同事提出了一种对原发性人急性髓系白血病（AML）进行大规模重编程为诱导多能干细胞（iPSC）的策略。他们表明，AML iPSC 的造血分化产生了具有与原始患者 AML 显著分子相似性的可移植白血病，为该疾病提供了新的模型和见解。见 Kotini 等人的相关文章，第 318 页（7）。
