两亲性阳离子奎宁衍生物对耐甲氧西林金黄色葡萄球菌抗菌活性的合成与评价
Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
作者信息
Lv Jian, Qian Yunbo, Liu Tingting, Wang Yongmei
机构信息
Department of Chemistry, The Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4102-6. doi: 10.1016/j.bmcl.2007.05.065. Epub 2007 May 24.
PMID:17570664
Abstract
Several representative amphiphilic cationic quinine-derived have been synthesized and evaluated against methicillin- resistant Staphylococcus aureus. This is the first reported antibacterial activity of this class of compounds. In vitro the minimal inhibitory concentration values of the best compound Q7 ranged from 0.4 to 1.6 microg/mL (MBC<3.2 microg/mL).
摘要
已经合成了几种具有代表性的两亲性阳离子奎宁衍生物，并对耐甲氧西林金黄色葡萄球菌进行了评估。这是此类化合物首次报道的抗菌活性。在体外，最佳化合物Q7的最低抑菌浓度值范围为0.4至1.6微克/毫升（最低杀菌浓度<3.2微克/毫升）。
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