Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Department of hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103569. doi: 10.1016/j.pdpdt.2023.103569. Epub 2023 Apr 15.
To evaluate the radial peripapillary capillary vessel density (RPC-VD) and thickness of the retinal nerve fiber layer (RNFL) in acute leukemia (AL) and the associations of these characteristics with blood laboratory parameters.
A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from February 2019 to April 2022. Sixty eyes of 30 patients diagnosed with AL and sixty eyes of 30 matched healthy controls were included. Optical coherence tomography angiography (OCTA) in the 4.5-mm Angio Disc scan mode and the Ganglion cell complex scan mode were performed for all participants. Correlation analyses were used to examine the associations of RPC-VD and RNFL with blood laboratory parameters.
Patients in the AL group had significantly increased RPC-VD in the whole-image (51.42±0.35 vs. 49.52±0.36) and peripapillary fields (53.90±0.43 vs. 51.17±0.50) compared with people in the control group (all P<0.001), while no difference was found for RPC-VD in the inside optic disk fields in the two groups. The RNFL in the AL group was significantly thicker than that in the control group (131.10±3.89 μm vs. 115.03±2.22 μm, P<0.05). Complete blood count (CBC) parameters, including red blood cells, hemoglobin and hematocrit, had a significant negative correlation with RPC-VD and RNFL (all P <0.05).
An increased RPC-VD and a thicker RNFL are evidence of fundus changes in patients with early-stage AL, and these metrics may be related to decreases in red blood cells, hemoglobin and hematocrit.
评估急性白血病（AL）患者的视盘周围毛细血管血管密度（RPC-VD）和视网膜神经纤维层（RNFL）厚度，并分析这些特征与血液实验室参数的相关性。
横断面研究于 2019 年 2 月至 2022 年 4 月在中山大学孙逸仙纪念医院眼科进行。共纳入 30 例 AL 患者的 60 只眼和 30 例匹配健康对照者的 60 只眼。所有参与者均行光学相干断层扫描血管造影（OCTA）4.5mm Angio Disc 扫描模式和神经节细胞复合体扫描模式。采用相关分析评估 RPC-VD 和 RNFL 与血液实验室参数的相关性。
AL 组患者全图像（51.42±0.35 vs. 49.52±0.36）和视盘周围区域（53.90±0.43 vs. 51.17±0.50）的 RPC-VD 显著高于对照组（均 P<0.001），但两组内视神经盘区域的 RPC-VD 无差异。AL 组的 RNFL 明显厚于对照组（131.10±3.89μm vs. 115.03±2.22μm，P<0.05）。全血细胞计数（CBC）参数，包括红细胞、血红蛋白和红细胞压积，与 RPC-VD 和 RNFL 呈显著负相关（均 P<0.05）。
早期 AL 患者存在视盘周围毛细血管血管密度增加和视网膜神经纤维层增厚，这些指标可能与红细胞、血红蛋白和红细胞压积减少有关。
