Jonsson S, Wallace R J, Hull S I, Musher D M
Am Rev Respir Dis. 1986 May;133(5):932-4.
The diagnosis of chronic granulomatous disease was made for the first time in a young adult when he presented with Nocardia asteroides pneumonia. Treatment with trimethoprim/sulfamethoxazole for 10 wk brought about an apparent cure of the infection. Two and one half years later N. asteroides pneumonia recurred and resulted in death from respiratory failure. Antibiotic susceptibility studies suggested that both episodes were caused by the same organism. This suggestion was supported by endonuclease restriction analysis, which showed that the plasmids from both Nocardia isolates were identical. Late recurrence of pneumonia caused by N. asteroides occurs only rarely. In this patient, recurrent infection appeared to be related to persistence of colonizing organisms in the host.
一名年轻成人因出现星形诺卡菌肺炎而首次被诊断为慢性肉芽肿病。用甲氧苄啶/磺胺甲恶唑治疗10周后，感染明显治愈。两年半后，星形诺卡菌肺炎复发，导致呼吸衰竭死亡。抗生素敏感性研究表明，这两次发作均由同一病原体引起。核酸内切酶限制性分析支持了这一观点，该分析显示，两种诺卡菌分离株的质粒相同。由星形诺卡菌引起的肺炎晚期复发极为罕见。在该患者中，反复感染似乎与宿主中定植菌的持续存在有关。
