长期诺卡菌病患者中星形诺卡菌和耳炎诺卡菌菌株持续性的分子研究
Molecular study of persistence of Nocardia asteroides and Nocardia otitidiscaviarum strains in patients with long-term nocardiosis.
作者信息
Provost F, Laurent F, Uzcategui L R, Boiron P
机构信息
Unité de Mycologie, Institut Pasteur, Paris, France.
出版信息
J Clin Microbiol. 1997 May;35(5):1157-60. doi: 10.1128/jcm.35.5.1157-1160.1997.
Abstract
Three Nocardia asteroides and five Nocardia otitidiscaviarum isolates recovered from three patients with long-term nocardiosis were compared by random amplification of polymorphic DNA fingerprinting, antibiotic susceptibility testing, and enzymatic characterization. Results obtained with primer DKU49 (P. Palittapongarnpim, S. Chomyc, A. Fanning, and D. Kunimoto, J. Infect. Dis. 167:975-978, 1993) provide evidence that patient A was infected by two N. asteroides strains during a single episode of nocardiosis and that patients B and C remained infected by the same strain, respectively. Resistance to minocycline that was present in the first isolate recovered from patient B reverted to intermediate resistance in the second isolate and reverted to susceptibility in the third isolate. Resistance to penicillin G and beta-lactams was acquired by the second isolate obtained from patient C.
摘要
从三名患有长期诺卡菌病的患者身上分离出的3株星形诺卡菌和5株耳炎诺卡菌，通过多态性DNA指纹随机扩增、药敏试验和酶学特性进行比较。用引物DKU49（P. Palittapongarnpim、S. Chomyc、A. Fanning和D. Kunimoto，《传染病杂志》167:975 - 978，1993年）获得的结果表明，患者A在单次诺卡菌病发作期间感染了两株星形诺卡菌，患者B和C分别仍被同一菌株感染。从患者B分离出的第一株菌株中存在的对米诺环素的耐药性在第二株菌株中恢复为中度耐药，并在第三株菌株中恢复为敏感。从患者C获得的第二株菌株获得了对青霉素G和β-内酰胺类的耐药性。
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