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精索静脉曲张是男科学的圣杯吗?

Are varicoceles the holy grail of Andrology?

作者信息

White Joshua, Cartaya Sofia, Black Kristian, Ledesma Braian, Arbelaez Maria Camila Suarez, Muthigi Akhil, Ramasamy Ranjith

机构信息

University of Miami Miller School of Medicine, Urology, Miami, FL, USA.

University of South Florida, Undergraduate Education, Tampa Bay, FL, USA.

出版信息

Int J Impot Res. 2024 May;36(3):177-180. doi: 10.1038/s41443-023-00696-3. Epub 2023 Apr 17.

DOI:10.1038/s41443-023-00696-3
PMID:37069437
Abstract

Varicoceles are a common condition affecting up to 15% of men in the general population, and up to 40% of men with infertility. A varicocele is an abnormal dilation of the veins within the scrotum, which can lead to reduced sperm production and testicular damage, resulting in infertility. Despite the prevalence of varicoceles, much remains to be discovered about their diagnosis, treatment, and long-term impact. Varicoceles are considered the 'holy grail' of Andrology because they represent a complex, multifactorial condition that requires a comprehensive approach to diagnosis and treatment. While surgical repair of varicoceles has been shown to improve fertility outcomes in some cases, there is still debate about the best approach to diagnosis and treatment, and long-term outcomes are not well understood. Advances in diagnostic imaging, such as color Doppler ultrasound, have improved our ability to identify varicoceles, but more research is needed to fully understand the impact of this condition on male fertility and overall health. As such, varicoceles represent an ongoing area of investigation in Andrology with much progress to be made in terms of diagnosis, treatment, and long-term impact.

摘要

精索静脉曲张是一种常见病症,在普通人群中影响高达15%的男性,在不育男性中影响高达40%。精索静脉曲张是阴囊内静脉的异常扩张,可导致精子生成减少和睾丸损伤,从而导致不育。尽管精索静脉曲张很常见,但关于其诊断、治疗和长期影响仍有许多有待发现之处。精索静脉曲张被认为是男科学的“圣杯”,因为它们代表一种复杂的多因素病症,需要采用综合方法进行诊断和治疗。虽然精索静脉曲张的手术修复在某些情况下已被证明可改善生育结果,但关于最佳诊断和治疗方法仍存在争议,而且长期结果尚未得到充分了解。诊断成像技术的进步,如彩色多普勒超声,提高了我们识别精索静脉曲张的能力,但仍需要更多研究来全面了解这种病症对男性生育能力和整体健康的影响。因此,精索静脉曲张是男科学中一个持续的研究领域,在诊断、治疗和长期影响方面还有很大的进展空间。

相似文献

1
Are varicoceles the holy grail of Andrology?精索静脉曲张是男科学的圣杯吗?
Int J Impot Res. 2024 May;36(3):177-180. doi: 10.1038/s41443-023-00696-3. Epub 2023 Apr 17.
2
Varicoceles: postoperative prevalence--a prospective study with color Doppler US.精索静脉曲张:术后患病率——一项彩色多普勒超声的前瞻性研究
Radiology. 1993 Jun;187(3):711-4. doi: 10.1148/radiology.187.3.8497618.
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Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis.精索静脉曲张与精子 DNA 损伤的关系及精索静脉曲张修复的效果:一项荟萃分析。
Reprod Biomed Online. 2012 Sep;25(3):307-14. doi: 10.1016/j.rbmo.2012.05.002. Epub 2012 May 23.
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Effects of varicocele on male fertility.精索静脉曲张对男性生育能力的影响。
Hum Reprod Update. 2001 Jan-Feb;7(1):59-64. doi: 10.1093/humupd/7.1.59.
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Surgical or radiological treatment for varicoceles in subfertile men.对不育男性精索静脉曲张的手术或放射治疗。
Cochrane Database Syst Rev. 2021 Apr 23;4(4):CD000479. doi: 10.1002/14651858.CD000479.pub6.
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Testicular varicoceles.睾丸静脉曲张
Clin Radiol. 2005 Dec;60(12):1248-55. doi: 10.1016/j.crad.2005.06.010.
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Imaging and interventional therapy for varicoceles.精索静脉曲张的影像学诊断与介入治疗。
Curr Urol Rep. 2014 Apr;15(4):399. doi: 10.1007/s11934-014-0399-0.
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Surgery or embolization for varicoceles in subfertile men.对不育男性精索静脉曲张进行手术或栓塞治疗。
Cochrane Database Syst Rev. 2012 Oct 17;10:CD000479. doi: 10.1002/14651858.CD000479.pub5.
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Adolescent Varicoceles and Infertility.青少年精索静脉曲张与不育症
Endocrinol Metab Clin North Am. 2015 Dec;44(4):835-42. doi: 10.1016/j.ecl.2015.07.007. Epub 2015 Aug 24.
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Varicoceles and male infertility.
Am Fam Physician. 1988 Feb;37(2):252-8.

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Diagnostic Approach to Equine Testicular Disorders.马睾丸疾病的诊断方法
Vet Sci. 2024 May 29;11(6):243. doi: 10.3390/vetsci11060243.
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Diagnosis and Management of Polyorchidism: A Case Report and Literature Review.多睾症的诊断与管理:一例病例报告及文献综述
Case Rep Urol. 2023 Jun 22;2023:1620276. doi: 10.1155/2023/1620276. eCollection 2023.

本文引用的文献

1
Developing a novel prediction model for the impact of varicocelectomy on postoperative fertility.开发一种关于精索静脉曲张切除术对术后生育能力影响的新型预测模型。
Eur J Transl Myol. 2022 May 2;32(2):10411. doi: 10.4081/ejtm.2022.10411.
2
Comparing Endovascular and Surgical Treatments for Varicocele: A Systematic Review and Meta-Analysis.比较精索静脉曲张的血管内和手术治疗:系统评价和荟萃分析。
J Vasc Interv Radiol. 2022 Jul;33(7):834-840.e2. doi: 10.1016/j.jvir.2022.03.013. Epub 2022 Mar 18.
3
The effects of varicocelectomy on the DNA fragmentation index and other sperm parameters: a meta-analysis.
精索静脉曲张切除术对DNA碎片化指数及其他精子参数的影响:一项荟萃分析
Basic Clin Androl. 2020 Sep 10;30:15. doi: 10.1186/s12610-020-00112-6. eCollection 2020.
4
Systematic Review of the Impact of Varicocele Grade on Response to Surgical Management.精索静脉曲张分级对手术治疗反应影响的系统评价。
J Urol. 2020 Jan;203(1):48-56. doi: 10.1097/JU.0000000000000311. Epub 2019 May 1.
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Best practice in the diagnosis and treatment of varicocele in children and adolescents.儿童和青少年精索静脉曲张诊断与治疗的最佳实践
Ther Adv Urol. 2018 Jun 22;10(9):273-282. doi: 10.1177/1756287218783900. eCollection 2018 Sep.
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Varicocele management for infertility and pain: A systematic review.精索静脉曲张不育症及疼痛的治疗:一项系统评价
Arab J Urol. 2017 Dec 14;16(1):157-170. doi: 10.1016/j.aju.2017.11.003. eCollection 2018 Mar.
7
Current Issues in Adolescent Varicocele: Pediatric Urological Perspectives.青少年精索静脉曲张的当前问题:儿科泌尿学视角
World J Mens Health. 2018 May;36(2):123-131. doi: 10.5534/wjmh.170053. Epub 2018 Mar 22.
8
Should we expand the indications for varicocele treatment?我们是否应该扩大精索静脉曲张治疗的适应症?
Transl Androl Urol. 2017 Oct;6(5):931-942. doi: 10.21037/tau.2017.08.01.
9
A systematic review and meta-analysis to determine the effect of sperm DNA damage on fertilization and intracytoplasmic sperm injection outcome.一项系统评价和荟萃分析,以确定精子DNA损伤对受精及卵胞浆内单精子注射结局的影响。
Asian J Androl. 2017 Jan-Feb;19(1):80-90. doi: 10.4103/1008-682X.182822.
10
Adolescent varicocele: limited indications for treatment during puberty and adolescence.青少年精索静脉曲张:青春期和青少年期治疗的适应证有限。
Transl Androl Urol. 2014 Dec;3(4):398-401. doi: 10.3978/j.issn.2223-4683.2014.12.10.