Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Inflammopharmacology. 2023 Jun;31(3):1289-1303. doi: 10.1007/s10787-023-01214-z. Epub 2023 Apr 17.
Atopic dermatitis (AD) is one of the most prevalent chronic skin inflammatory disorders requiring continuous treatment and care. Pterostilbene (PTN) belongs to stilbene and is a polyphenolic compound of natural origin. It is similar to resveratrol and has analogous anti-inflammatory, anti-oxidant, and anti-carcinogenic characteristics. This study was intended to evaluate the effect of PTN against atopic dermatitis. The disease was induced by sensitization with 2,4-dinitrochlorobenzene (DNCB) in mice. The standard control group (SCG) received topical 0.1% tacrolimus (TC), whereas three other treatment groups received daily topical PTN at 0.2, 0.6, and 1% w/w for 28 days. Dermatitis scoring, ear thickness, and body weight of animals were weekly determined while other parameters were assessed at the termination of the experiment. PTN reduced the ear weight, skin thickness, and the weight and size of thymus glands and spleen in comparison with diseased animals. PTN also reduced the elevated immunoglobulin E (IgE) level and blood inflammatory cells in diseased mice. The histopathological findings showed a decreased epidermal thickness in PTN-treated groups. Moreover, treatment with PTN improved the amount of oxidative stress markers in the skin of the diseased mice. The expressions of IL-4, IL-6, TNF-α, and NF-κB in the skin of diseased mice were also reduced by PTN. This study concludes that PTN ameliorated the symptoms of atopic dermatitis through the reduction of inflammation, oxidative damage, and inflammatory cytokines in the skin of diseased animals. Therefore, PTN must be further investigated for the treatment of AD complications and other inflammatory skin disorders.
特应性皮炎（AD）是最常见的慢性皮肤炎症性疾病之一，需要持续治疗和护理。紫檀芪（PTN）属于芪类，是一种天然来源的多酚化合物。它与白藜芦醇相似，具有类似的抗炎、抗氧化和抗癌特性。本研究旨在评估 PTN 对特应性皮炎的作用。该疾病通过用 2,4-二硝基氯苯（DNCB）致敏小鼠而诱发。标准对照组（SCG）接受 0.1%他克莫司（TC）的局部治疗，而另外三个治疗组则每天接受 0.2%、0.6%和 1%w/w 的 PTN 局部治疗，共 28 天。每周测定动物的皮炎评分、耳厚度和体重，而在实验结束时评估其他参数。与患病动物相比，PTN 降低了耳重、皮肤厚度以及胸腺和脾脏的重量和大小。PTN 还降低了患病小鼠升高的免疫球蛋白 E（IgE）水平和血液炎症细胞。组织病理学检查结果显示，PTN 治疗组的表皮厚度降低。此外，PTN 改善了患病小鼠皮肤中氧化应激标志物的含量。PTN 还降低了患病小鼠皮肤中白细胞介素-4（IL-4）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和核因子-κB（NF-κB）的表达。本研究得出结论，PTN 通过减轻患病动物皮肤中的炎症、氧化损伤和炎症细胞因子，改善了特应性皮炎的症状。因此，PTN 必须进一步研究用于治疗 AD 并发症和其他炎症性皮肤疾病。
