University of Virginia, Charlottesville, Virginia, USA.
Laboratório Bacchi, Botucatu, Brazil.
J Cutan Pathol. 2023 Jul;50(7):606-610. doi: 10.1111/cup.14431. Epub 2023 Apr 17.
Aleukemic leukemia cutis (ALC) is a rare condition that is characterized by leukemic cells in the skin before presenting in the peripheral blood or bone marrow. We report a case of a 43-year-old woman who underwent assessment for bilateral facial nodules arising 1 month after COVID-19 infection. A punch biopsy specimen showed a malignant neoplasm primarily composed of immature blasts dissecting through the collagen in the dermis, concerning for myeloid sarcoma versus leukemia cutis. Bone marrow and blood specimens were negative for hematologic malignancy. The patient was appropriately treated with chemotherapy and is recovering well. This report highlights an interesting case of ALC following COVID-19 infection presenting as an isolated facial rash. Whether there is a true relationship between the patient's COVID-19 infection and her abrupt presentation of leukemia remains unclear, but we present this case regardless, in an effort to highlight a potentially unique association requiring further study.
无髓性白血病皮肤浸润（ALC）是一种罕见的疾病，其特征是在外周血或骨髓出现白血病细胞之前，皮肤中已有白血病细胞。我们报告了一例 43 岁女性病例，她在 COVID-19 感染后 1 个月因双侧面部结节就诊。一个打孔活检标本显示一种主要由不成熟的原始细胞构成的恶性肿瘤，这些原始细胞穿过真皮中的胶原纤维，考虑为髓样肉瘤与白血病皮肤浸润。骨髓和血液标本均未发现血液系统恶性肿瘤。患者接受了适当的化疗，恢复良好。本报告强调了一例有趣的 COVID-19 感染后 ALC 病例，表现为孤立性面部皮疹。患者的 COVID-19 感染与她突然出现的白血病之间是否存在真正的关系尚不清楚，但我们仍然提出了这个病例，以努力强调一种可能需要进一步研究的独特关联。
