Tsitsi Panagiota, Nilsson Mattias, Seimyr Gustaf Öqvist, Larsson Olof, Svenningsson Per, Markaki Ioanna
Department of Clinical Neuroscience Neuro, Karolinska Institutet Stockholm Sweden.
Center of Neurology Academic Specialist Center Stockholm Sweden.
Mov Disord Clin Pract. 2023 Feb 14;10(4):579-585. doi: 10.1002/mdc3.13663. eCollection 2023 Apr.
Reading difficulties are commonly reported in Parkinson's disease (PD). So far, only a few studies have assessed reading in PD, most of them confirming a different pattern in patients compared with healthy populations. Impaired oculomotor control is an early feature of PD. Cognitive deficits, on the other hand, may appear early, but they are most prominent at later stages. Although these two factors are thought to be responsible for the alterations in reading performance, it is unclear how each factor contributes to them.
To evaluate eye movements during reading in PD and healthy controls (HCs).
Data from 42 HCs (36% men) and 48 patients with PD (67% men) at Hoehn and Yahr stages ≤3 were analyzed. PD participants were further divided into 2 groups based on their Montreal Cognitive Assessment (MoCA) score using a cutoff of ≥26. Eye movements were recorded with Tobii Pro Spectrum, a screen-based eye tracker with a sampling rate of 1200 Hz.
PD participants performed fewer fixations per second ( = 0.033), with a longer mean ( = 0.037) and standard deviation fixation duration ( = 0.033) than HC, and further analysis showed that only patients with a lower MoCA score performed worse than HCs. Reading parameters were weakly associated with MoCA scores, irrespective of age and education.
Changes in the reading pattern of PD patients are probably attributed to cognitive rather than pure oculomotor alterations.
帕金森病（PD）患者中普遍存在阅读困难的情况。到目前为止，仅有少数研究评估了PD患者的阅读情况，其中大多数研究证实，与健康人群相比，患者的阅读模式有所不同。动眼控制受损是PD的早期特征。另一方面，认知缺陷可能在疾病早期就会出现，但在疾病后期最为明显。尽管这两个因素被认为是导致阅读表现改变的原因，但尚不清楚每个因素对阅读表现的具体影响程度。
评估PD患者和健康对照者（HCs）在阅读过程中的眼动情况。
分析了42名HCs（男性占36%）和48名Hoehn和Yahr分期≤3期的PD患者（男性占67%）的数据。根据蒙特利尔认知评估（MoCA）得分≥26的临界值，将PD参与者进一步分为两组。使用Tobii Pro Spectrum（一种基于屏幕的眼动追踪仪，采样率为1200 Hz）记录眼动情况。
与HCs相比，PD参与者每秒的注视次数更少（P = 0.033），平均注视持续时间更长（P = 0.037），注视持续时间的标准差更大（P = 0.033），进一步分析表明，只有MoCA得分较低的患者表现比HCs更差。阅读参数与MoCA得分呈弱相关，与年龄和教育程度无关。
PD患者阅读模式的改变可能归因于认知因素，而非单纯的动眼改变。
