Department of Gastroenterology, West China Hospital, Sichuan University, No.37, Guo Xue Alley, Wu Hou District, Chengdu City, 610041, Sichuan Province, China.
The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Curr Microbiol. 2023 Apr 18;80(5):185. doi: 10.1007/s00284-023-03264-6.
Helicobacter pylori (H. pylori) has coevolved with its human host for more than 100 000 years. It can safely colonize around the epithelium of gastric glands via their specific microstructures and proteins. Unless patients receive eradication treatment, H. pylori infection is always lifelong. However, few studies have discussed the reasons. This review will focus on the adhesion of H. pylori from the oral cavity to gastric mucosa and summarize the possible binding and translocation characteristics. Adhesion is the first step for persistent colonization after the directional motility, and factors related to adhesion are necessary. Outer membrane proteins, such as the blood group antigen binding adhesin (BabA) and the sialic acid binding adhesin (SabA), play pivotal roles in binding to human mucins and cellular surfaces. And this may offer different perspectives on eradication.
幽门螺杆菌（H. pylori）与其人类宿主共同进化了超过 10 万年。它可以通过其特定的微观结构和蛋白质安全地定植在胃腺上皮周围。除非患者接受根除治疗，否则 H. pylori 感染总是终身的。然而，很少有研究讨论其原因。本综述将重点关注 H. pylori 从口腔到胃黏膜的黏附，并总结可能的结合和转移特征。黏附是定向运动后持续定植的第一步，与黏附相关的因素是必要的。外膜蛋白，如血型抗原结合黏附素（BabA）和唾液酸结合黏附素（SabA），在与人黏蛋白和细胞表面结合中起关键作用。这可能为根除治疗提供不同的视角。
