Reichel W, Weber K J
Arch Orthop Trauma Surg (1978). 1986;105(1):11-7. doi: 10.1007/BF00625653.
An inflammatory arthritis was induced in rabbit knees by intra-articular injection of human IgG complex in immunized animals. A increased invasion of large plasma proteins into the arthritic knee could be measured by electrophoretic separation of synovial extract and autoradiographic detection of 125I-labeled proteins. Synovectomy resulted in a reduced invasion of plasma proteins compared with the preoperatively arthritic knees. This protective effect was lost, however, following repeated intra-articular IgG injections. Fibrosis and decreased vascularization of the synovectomized knee, the excision of inflammatory cells, and mediators of inflammation are discussed as possible explanations.
通过在免疫动物的膝关节内注射人IgG复合物，在兔膝关节中诱发炎性关节炎。通过对滑膜提取物进行电泳分离并对125I标记的蛋白质进行放射自显影检测，可以测量到大量血浆蛋白向关节炎膝关节的侵入增加。与术前患有关节炎的膝关节相比，滑膜切除术导致血浆蛋白的侵入减少。然而，在反复进行关节内注射IgG后，这种保护作用消失了。滑膜切除膝关节的纤维化和血管化减少、炎性细胞的切除以及炎症介质被讨论为可能的解释。
