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抗原竞争研究。I. 兔免疫球蛋白G的Fc片段和Fab片段在小鼠体内的抗原竞争

Studies on antigenic competition. I. Antigenic competition between the Fc and Fab fragments of rabbit IgG in mice.

作者信息

Taussig M J

出版信息

Immunology. 1971 Jul;21(1):51-60.

PMID:5558032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408097/
Abstract

In the antibody response to rabbit IgG in BALB/c mice, antigenic competition has been demonstrated between Fc and Fab'. Similar competition was found when a mixture of Fc and Fab' was used as antigen. In both cases the presence of Fc suppressed the antibody response to Fab'. Competition was demonstrable only in the primary antibody response. The effect on competition of varying the routes and the time course of administration of the antigens was investigated.

摘要

在BALB/c小鼠对兔IgG的抗体应答中，已证实Fc和Fab'之间存在抗原竞争。当使用Fc和Fab'的混合物作为抗原时，也发现了类似的竞争。在这两种情况下，Fc的存在均抑制了对Fab'的抗体应答。竞争仅在初次抗体应答中可得到证实。研究了改变抗原给药途径和时间进程对竞争的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e2d/1408097/98cd2cb20001/immunology00354-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e2d/1408097/98cd2cb20001/immunology00354-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e2d/1408097/98cd2cb20001/immunology00354-0059-a.jpg

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本文引用的文献

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The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
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Antigenic competition: cellular or humoral.抗原竞争：细胞性或体液性。
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Immunology. 1972 Feb;22(2):185-97.
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Antigenic competition between polypeptidyl determinants in normal and tolerant rabbits.正常和耐受兔中多肽基决定簇之间的抗原竞争
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7
The specificity of the early immune response. I. A comparison of the specificity of delayed hypersensitivity and humoral responses following immunization with human gammaG globulin.早期免疫反应的特异性。I. 用人γG球蛋白免疫后迟发型超敏反应和体液反应特异性的比较。
J Immunol. 1969 Sep;103(3):519-27.
8
An antigen-binding capacity test for human immunoglobulin G (IgG) fragments.人免疫球蛋白G（IgG）片段的抗原结合能力测试。
J Immunol. 1968 Sep;101(3):433-8.
9
Competition of haptens.半抗原的竞争
J Exp Med. 1966 Sep 1;124(3):293-306. doi: 10.1084/jem.124.3.293.
10
Bacteriophage linked assays for antibodies to protein antigens.针对蛋白质抗原抗体的噬菌体连接检测法
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