R&D Center, ROKIT Healthcare, Inc., Seoul, Korea.
Department of Biomicrosystem Technology, Korea University, Seoul, Korea.
Clin Transl Sci. 2023 Jul;16(7):1121-1126. doi: 10.1111/cts.13528. Epub 2023 Apr 20.
Recently, the field of regenerative medicine has made great strides in the development of new treatments for various organ dysfunctions. One of the most promising new approaches is the use of three-dimensional (3D) printing and autologous tissues. In this study, we evaluated the safety of a 3D-printed autologous omentum patch to kidneys using large animals. A total of seven micropigs underwent transplantation of the 3D-printed autologous omentum patch. Twelve weeks after transplantation, the safety was evaluated by measuring body weight, blood, and the renal resistive index. In addition, biopsy samples were histologically analyzed. The results showed no surgical complications, renal functional hematological changes, or inflammatory responses. Therefore, this study provides important insights into direct therapy to kidneys with a 3D-printed patch made of autologous tissue. Furthermore, it has the potential for the development of new therapies for various organ dysfunction.
最近，再生医学领域在开发各种器官功能障碍的新治疗方法方面取得了重大进展。最有前途的新方法之一是使用三维（3D）打印和自体组织。在这项研究中，我们使用大型动物评估了用于肾脏的 3D 打印自体大网膜补片的安全性。共有 7 只微型猪接受了 3D 打印自体大网膜补片的移植。移植后 12 周，通过测量体重、血液和肾阻力指数来评估安全性。此外，还对活检样本进行了组织学分析。结果显示无手术并发症、肾功能血液学变化或炎症反应。因此，这项研究为使用 3D 打印的自体组织补片直接治疗肾脏提供了重要的见解。此外，它还有可能为各种器官功能障碍的新疗法的发展提供帮助。
