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土壤细菌sp. 菌株FERM BP - 3421（剪接抑制素产生菌）的全基因组序列

Complete Genome Sequence of Soil Bacterium sp. Strain FERM BP-3421, a Producer of Spliceostatins.

作者信息

Kunakom Sylvia, Adaikpoh Barbara I, Tran Tuan Anh, Eustáquio Alessandra S

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.

Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.

出版信息

Microbiol Resour Announc. 2023 May 17;12(5):e0011123. doi: 10.1128/mra.00111-23. Epub 2023 Apr 19.

DOI:10.1128/mra.00111-23
PMID:37074205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10190677/
Abstract

Here, we report the complete genome sequence of sp. strain FERM BP-3421, a bacterium isolated previously from a soil sample in Japan. Strain FERM BP-3421 produces spliceostatins, which are splicing modulatory antitumor agents that advanced to preclinical development. The genome is composed of four circular replicons of 3.90, 3.0, 0.59, and 0.24 Mbp.

摘要

在此，我们报告了sp. 菌株FERM BP - 3421的全基因组序列，该菌株是先前从日本的一份土壤样本中分离得到的。FERM BP - 3421菌株产生剪接抑制素，这是一类已进入临床前开发阶段的剪接调节抗肿瘤药物。该基因组由四个环状复制子组成，大小分别为390万碱基对、300万碱基对、59万碱基对和24万碱基对。

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