Son Y S, Zilversmit D B
Arteriosclerosis. 1986 May-Jun;6(3):345-51.
Three models of hypercholesterolemia in rabbits were positively associated with plasma cholesteryl ester and triglyceride transfer activities. In cholesterol-fed rabbits, the transfer activities increased two- to three-fold when plasma cholesterol concentration reached about 1500 mg/dl. In hypercholesterolemia induced by feeding a cholesterol-free semisynthetic casein-sucrose diet, plasma cholesterol increased up to three-fold and the increase in cholesteryl ester and triglyceride transfer activities per unit of plasma cholesterol increment was similar to that in cholesterol-fed rabbits. Watanabe heritable hyperlipidemic rabbits, in which hypercholesterolemia is induced by a genetic defect of the LDL receptor, had significantly higher transfer activities than normolipidemic rabbits. However, fasting, which also induced hypercholesterolemia, lowered transfer activities, whereas refeeding returned them to prefasting levels. In rats, hypercholesterolemia induced by a high cholesterol diet did not increase cholesteryl ester and triglyceride transfer activities. Although hypercholesterolemia in rabbits may not be the primary cause of increased lipid transfer activities, some mechanism related to hypercholesterolemia appears to be associated with increased cholesteryl ester and triglyceride transfer activities.
家兔的三种高胆固醇血症模型与血浆胆固醇酯及甘油三酯转运活性呈正相关。在喂食胆固醇的家兔中，当血浆胆固醇浓度达到约1500mg/dl时，转运活性增加两到三倍。在喂食不含胆固醇的半合成酪蛋白-蔗糖饮食诱导的高胆固醇血症中，血浆胆固醇增加高达三倍，每单位血浆胆固醇增量的胆固醇酯和甘油三酯转运活性增加与喂食胆固醇的家兔相似。渡边遗传性高脂血症家兔，其高胆固醇血症由低密度脂蛋白受体的遗传缺陷引起，其转运活性显著高于正常血脂家兔。然而，禁食也会诱导高胆固醇血症，会降低转运活性，而重新喂食则会使其恢复到禁食前水平。在大鼠中，高胆固醇饮食诱导的高胆固醇血症不会增加胆固醇酯和甘油三酯转运活性。虽然家兔的高胆固醇血症可能不是脂质转运活性增加的主要原因，但一些与高胆固醇血症相关的机制似乎与胆固醇酯和甘油三酯转运活性增加有关。
