Baer A N, Woosley R L, Pincus T
Arthritis Rheum. 1986 Apr;29(4):508-14. doi: 10.1002/art.1780290408.
An association between host acetylator phenotype and idiopathic systemic lupus erythematosus (SLE) has been sought for over a decade, without a definitive result. We have observed that the frequency of the slow acetylator phenotype was similar in 64 patients with idiopathic SLE (38%), 60 healthy volunteers (50%), and 52 non-SLE medical service patients (44%). The slow acetylator phenotype was not more frequent among subgroups of the SLE patients defined by demographic features or specific manifestations of disease. Our results, as well as a majority of previously published results, do not provide evidence for an association between acetylator phenotype and idiopathic SLE.
十多年来，人们一直在探寻宿主乙酰化酶表型与特发性系统性红斑狼疮（SLE）之间的关联，但尚无明确结果。我们观察到，64例特发性SLE患者（38%）、60名健康志愿者（50%）和52名非SLE内科患者（44%）中慢乙酰化酶表型的频率相似。慢乙酰化酶表型在根据人口统计学特征或疾病特定表现定义的SLE患者亚组中并不更常见。我们的结果以及大多数先前发表的结果均未提供乙酰化酶表型与特发性SLE之间存在关联的证据。
