Vansant J, Woosley R L, John J T, Sergent J S
Arthritis Rheum. 1978 Mar;21(2):192-5. doi: 10.1002/art.1780210203.
Previous reports have indicated that idiopathic systemic lupus erythematosus (SLE), like drug-induced lupus, is more frequent in "slow" hepatic acetylators. Using dapsone acetylation rate to determine phenotypes, we found that of the 18 SLE patients studied, 9 were fast acetylators, 8 were slow, and 1 was indeterminate. This result (53% fast) is similar to acetylator phenotypes in our normal controls (50% fast) and in the population at large (52%).
先前的报告指出，特发性系统性红斑狼疮（SLE）与药物性狼疮一样，在“慢”型肝脏乙酰化酶人群中更为常见。通过使用氨苯砜乙酰化速率来确定表型，我们发现，在所研究的18例SLE患者中，9例为快乙酰化酶型，8例为慢乙酰化酶型，1例不确定。这一结果（53%为快乙酰化酶型）与我们正常对照人群（50%为快乙酰化酶型）以及总体人群（52%）的乙酰化酶表型相似。
