Marsden J R, Mason G G, Coburn P R, Rawlins M D, Shuster S
Eur J Clin Pharmacol. 1985;28(4):387-90. doi: 10.1007/BF00544355.
Acetylator phenotype was measure in 58 patients presenting to a skin clinic with discoid lupus erythematosus (DLE) and in 51 normal healthy subjects. Twenty seven of the patients with DLE were found to have evidence of systemic lupus erythematosus (D+SLE). Frequency of slow acetylator phenotype was 58% in all DLE patients, 52% in those with D+SLE and was no different from the 57% in controls. The distribution of acetylator phenotypes within the groups with DLE and those with D+SLE was similar to controls. Severity of DLE was assessed as number of skin lesions and median lesion count was 11.5 in slow acetylators and 10 in fast acetylators but in D+SLE median lesion count was 22 in slow acetylators and 12 in fast acetylators, and there was a significant inverse relationship between lesion count and rate of acetylation; scores for systemic involvement showed no relationship. We conclude that there is no difference in the frequency or distribution of slow acetylator phenotype between normal subjects and patients with DLE with or without SLE but that actual rate of acetylation may determine severity of expression of the disease in slow acetylators.
对58名到皮肤科门诊就诊的盘状红斑狼疮（DLE）患者以及51名正常健康受试者进行了乙酰化酶表型检测。发现27例DLE患者有系统性红斑狼疮（D+SLE）的证据。所有DLE患者中慢乙酰化酶表型的频率为58%，D+SLE患者中为52%，与对照组的57%无差异。DLE组和D+SLE组内乙酰化酶表型的分布与对照组相似。DLE的严重程度通过皮肤病变数量评估，慢乙酰化酶者的病变中位数为11.5，快乙酰化酶者为10，但在D+SLE中，慢乙酰化酶者的病变中位数为22，快乙酰化酶者为12，病变数量与乙酰化率之间存在显著负相关；系统性受累评分无相关性。我们得出结论，正常受试者与有或无SLE的DLE患者之间慢乙酰化酶表型的频率或分布没有差异，但实际乙酰化率可能决定慢乙酰化酶者疾病表达的严重程度。
