特发性系统性红斑狼疮中的乙酰化酶表型

Acetylator phenotype in idiopathic systemic lupus erythematosus.

作者信息

Reidenberg M M, Levy M, Drayer D E, Zylber-Katz E, Robbins W C

出版信息

Arthritis Rheum. 1980 May;23(5):569-73. doi: 10.1002/art.1780230508.

Abstract

The acetylator phenotypes of 21 patients from New York City and 29 patients from Israel with idiopathic systemic lupus erythematosus (SLE) were determined with dapsone or isoniazid. Thirty were slwo acetylators, 17 were rapid, and 3 indeterminate. These cases plus published studies of acetylator phenotypes in idiopathic SLE show a worldwide distribution of 150 slow to 77 rapid instead of the expected 122:105 (P less than 0.001). The relationship between acetylator phenotype and possible etiologic agents is discussed.

摘要

采用氨苯砜或异烟肼测定了21例来自纽约市和29例来自以色列的特发性系统性红斑狼疮（SLE）患者的乙酰化酶表型。其中30例为慢乙酰化酶，17例为快乙酰化酶，3例结果不确定。这些病例加上已发表的关于特发性SLE乙酰化酶表型的研究表明，全球范围内慢乙酰化酶与快乙酰化酶的分布比例为150:77，而非预期的122:105（P<0.001）。本文还讨论了乙酰化酶表型与可能的病因之间的关系。