Robinson D R, Prickett J D, Makoul G T, Steinberg A D, Colvin R B
Arthritis Rheum. 1986 Apr;29(4):539-46. doi: 10.1002/art.1780290412.
Previous studies have shown that dietary marine lipids containing large quantities of n-3 polyunsaturated fatty acids, administered to (New Zealand black X New Zealand white)F1 and MRL-lpr/lpr mice before the development of renal disease, reduce the severity of glomerulonephritis in mice of these strains. The present study demonstrated that delayed administration of a marine lipid diet, 25% menhaden oil (MO) by weight, until after the onset of overt renal disease, also resulted in significant improvement in rates of mortality, proteinuria, and histologic evidence of glomerular injury, compared with control animals fed a diet that contained mostly saturated fatty acids, 25% beef tallow. The MO diet also reduced the histologic severity of renal disease in male BXSB/MpJ and male MRL-lpr/lpr mice. In contrast, necrotizing vasculitis was more frequent in small and medium-sized renal arteries of the MRL-lpr/lpr mice fed MO than in those fed beef tallow (33.4% versus 7.6%, respectively).
先前的研究表明，在肾病发展之前给（新西兰黑×新西兰白）F1和MRL-lpr/lpr小鼠喂食含有大量n-3多不饱和脂肪酸的海洋脂质饮食，可减轻这些品系小鼠的肾小球肾炎严重程度。本研究表明，直到明显的肾病发作后才开始延迟给予海洋脂质饮食（按重量计25%的鲱鱼油），与喂食主要含饱和脂肪酸（25%牛脂）饮食的对照动物相比，死亡率、蛋白尿以及肾小球损伤的组织学证据发生率也有显著改善。鲱鱼油饮食还降低了雄性BXSB/MpJ和雄性MRL-lpr/lpr小鼠肾病的组织学严重程度。相比之下，喂食鲱鱼油的MRL-lpr/lpr小鼠中小和中等大小肾动脉的坏死性血管炎比喂食牛脂的小鼠更常见（分别为33.4%和7.6%）。
