Department of Surgical Oncology, Georges François Leclerc Cancer Center -UNICANCER, Dijon, France.
Department of Radiotherapy, Georges François Leclerc Cancer Center - UNICANCER, Dijon, France.
Cancer Rep (Hoboken). 2023 May;6(5):e1823. doi: 10.1002/cnr2.1823. Epub 2023 Apr 19.
There is no international consensus for management of early-stage cervical cancer (ESCC). This study aimed to retrospectively investigate disease-free survival (DFS) and overall survival (OS) in patients with ESCC according to the therapeutic strategy used, surgery alone versus preoperative radiation following by surgery.
Data were retrospectively collected from 1998 to 2015 using the Gynecological Cancer Registry of the Côte d'Or. The inclusion criteria were FIGO 2018 ≤ IB2; squamous cell carcinoma, adenocarcinoma or adenosquamous type. Survival curves were compared using the log-rank test.
One hundred twenty-six patients were included. Median survival was 90 months. There was no significant difference in DFS (HR = 0.91, 95%CI [0.32-2.53], p = 0.858) or in OS between surgery alone versus preoperative radiation following by surgery (HR = 0.97, 95%CI [0.31-2.99], p = 0.961). In the subgroup of patients with stage ≥IB1, there was no significant difference in DFS (HR = 3.26, p = 0.2) or in OS (HR = 3.87, p = 0.2).
Our study did not identify any difference in survival according to the treatment strategy. Preoperative radiation following by surgery can be an alternative to surgery alone for ESCC.
早期宫颈癌（ESCC）的治疗尚无国际共识。本研究旨在根据治疗策略回顾性调查 ESCC 患者的无病生存率（DFS）和总生存率（OS），即单独手术与术前放疗联合手术。
使用科多尔妇科癌症登记处的数据，从 1998 年至 2015 年进行了回顾性收集。纳入标准为 FIGO 2018≤IB2；鳞癌、腺癌或腺鳞癌。使用对数秩检验比较生存曲线。
共纳入 126 例患者。中位生存时间为 90 个月。单独手术与术前放疗联合手术的 DFS（HR=0.91，95%CI[0.32-2.53]，p=0.858）或 OS（HR=0.97，95%CI[0.31-2.99]，p=0.961）无显著差异。在≥IB1 期患者亚组中，DFS（HR=3.26，p=0.2）或 OS（HR=3.87，p=0.2）也无显著差异。
我们的研究未发现治疗策略的生存差异。术前放疗联合手术可以作为 ESCC 患者的单独手术替代方案。
