BACKGROUND

The most common bacteria causing periodontitis were and . At present, plants are considered a valuable source of natural materials for use in the development of antimicrobial, anti-inflammatory and antioxidant agents. or red dragon fruit peel extract (RDFPE) contains terpenoids, and flavonoids can be an alternative. The gingival patch (GP) has been designed to ensure drug delivery and absorption into tissue targets.

OBJECTIVE

To assess the effect of a mucoadhesive gingival patch containing nano-emulsion of red dragon fruit peel extract (GP-nRDFPE) in inhibiting and as compared to control groups.

MATERIAL AND METHOD

Inhibition by diffusion method was carried out in and medium. The test material was gingival patch mucoadhesive containing nano-emulsion red dragon fruit peel extract (GP-nRDFPR), gingival patch mucoadhesive containing red dragon fruit peel extract (GP-RDFPE), gingival patch mucoadhesive containing doxycycline (GP-dcx) and blank gingival patch (GP), conducted in four replications. The differences in the inhibition were analyzed using ANOVA and post hoc tests (p < 0.05).

RESULT

GP-nRDFPE showed higher inhibition in and compared to GP-RDFPE at the concentrations 3.125% and 6.25% (p < 0.05).

CONCLUSION

The GP-nRDFPE showed better anti-periodontic bacteria to , , and in line with its concentration. This is assumed that the GP-nRDFPE can use as periodontitis treatment.