Garrett Ariane, Kim Byungchan, Sie Edbert J, Gurel Nil Z, Marsili Francesco, Boas David A, Roblyer Darren
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Reality Labs, Meta Platforms Inc., Menlo Park, CA 94025, USA.
Biomed Opt Express. 2023 Mar 23;14(4):1594-1607. doi: 10.1364/BOE.482740. eCollection 2023 Apr 1.
Non-invasive continuous blood pressure monitoring remains elusive. There has been extensive research using the photoplethysmographic (PPG) waveform for blood pressure estimation, but improvements in accuracy are still needed before clinical use. Here we explored the use of an emerging technique, speckle contrast optical spectroscopy (SCOS), for blood pressure estimation. SCOS provides measurements of both blood volume changes (PPG) and blood flow index (BFi) changes during the cardiac cycle, and thus provides a richer set of parameters compared to traditional PPG. SCOS measurements were taken on the finger and wrists of 13 subjects. We investigated the correlations between features extracted from both the PPG and BFi waveforms with blood pressure. Features from the BFi waveforms were more significantly correlated with blood pressure than PPG features ( for the top BFi feature versus for the top PPG feature). Importantly, we also found that features combining BFi and PPG data were highly correlated with changes in blood pressure ( ). These results suggest that the incorporation of BFi measurements should be further explored as a means to improve blood pressure estimation using non-invasive optical techniques.
无创连续血压监测仍然难以实现。已经有大量研究使用光电容积脉搏波描记法（PPG）波形来估计血压，但在临床应用之前仍需要提高准确性。在此，我们探索了一种新兴技术——散斑对比光学光谱法（SCOS）用于血压估计。SCOS可测量心动周期中的血容量变化（PPG）和血流指数（BFi）变化，因此与传统PPG相比提供了更丰富的参数集。对13名受试者的手指和手腕进行了SCOS测量。我们研究了从PPG和BFi波形中提取的特征与血压之间的相关性。BFi波形的特征与血压的相关性比PPG特征更显著（最高BFi特征的相关性为 ，而最高PPG特征的相关性为 ）。重要的是，我们还发现结合BFi和PPG数据的特征与血压变化高度相关（ ）。这些结果表明，应进一步探索纳入BFi测量作为使用无创光学技术改善血压估计的一种方法。
