Rice Tyler B, Yang Bruce, White Sean
Laser Associated Sciences, Inc., CA 92612, USA.
Biomed Opt Express. 2020 Aug 31;11(9):5352-5361. doi: 10.1364/BOE.403501. eCollection 2020 Sep 1.
Recent advances in optical technology have emerged for measuring blood flow in the extremities using speckleplethysmography (SPG), which may address needs in vascular medicine and other fields. SPG has demonstrated a highly linear response with flow rate, but the susceptibility to differences in skin tone is unclear. Two validation studies using skin-simulating phantoms and a simple clinical protocol were conducted to determine the impact of absorbing skin layers on SPG measurements. Benchtop results demonstrated that the coefficient of determination between known flow rate and SPG was highly linear (R = 0.990) and was unaffected by the addition of skin-phantom layers with variable absorption (R = 0.996-0.999). Additionally, no significant trend was found between the fit residuals of SPG and flow rate with increasing skin-phantom absorption (R=0.025, p = 0.29). In clinical testing, no significant difference was found using both a 4-way ANOVA between demographic classifications (F = 0.89, p = 0.45), and a 2-way ANOVA test between lower- and higher-melanin subclassifications (F = 0.4, p = 0.52).
光学技术最近取得了进展，出现了利用散斑容积脉搏波描记法（SPG）测量四肢血流的方法，这可能满足血管医学和其他领域的需求。SPG已证明与流速具有高度线性响应，但对肤色差异的敏感性尚不清楚。进行了两项使用皮肤模拟体模和简单临床方案的验证研究，以确定吸收性皮肤层对SPG测量的影响。台式实验结果表明，已知流速与SPG之间的决定系数呈高度线性（R = 0.990），并且不受添加具有可变吸收性的皮肤体模层的影响（R = 0.996 - 0.999）。此外，随着皮肤体模吸收性增加，SPG的拟合残差与流速之间未发现显著趋势（R = 0.025，p = 0.29）。在临床测试中，使用人口统计学分类的四因素方差分析（F = 0.89，p = 0.45）以及低黑色素和高黑色素亚分类之间的双因素方差分析测试（F = 0.4，p = 0.52）均未发现显著差异。
