家庭诊室联合漂白方案的疗效：一项随机对照临床试验。

The Efficacy of At-home, In-office, and Combined Bleaching Regimens: A Randomized Controlled Clinical Trial.

机构信息

†Bing-jie Zhong, DDS, PhD candidate, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

†Song Yang, DDS, MS, PhD candidate, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

出版信息

Oper Dent. 2023 May 1;48(3):E71-E80. doi: 10.2341/22-099-C.

DOI:10.2341/22-099-C

PMID:37079917

Abstract

OBJECTIVE

The aim of this study was to compare the clinical efficacy of at-home, in-office, and combined bleaching regimens.

METHODS

Forty-eight participants were recruited and randomly divided into four groups based on the bleaching regimen (n=12) as follows: 1) at-home bleaching using 10% carbamide peroxide (Opalescence PF 10%, Ultradent) for 14 days (HB); 2) two sessions of in-office bleaching using 40% hydrogen peroxide (Opalescence BOOST PF 40%, Ultradent) with a one-week interval (OB); 3) one session of in-office bleaching followed by at-home bleaching for seven days (OHB); and 4) at-home bleaching for seven days followed by one session of in-office bleaching (HOB). Tooth color was measured using a spectrophotometer (Easyshade, Vita ZahnFabrik) at baseline (T0), day 8 (T1), day 15 (T2), and day 43 (T3, four weeks after the end of the bleaching treatment). The color data were calculated using the CIEDE2000 (ΔE00) and whiteness index for dentistry (WID) formulas. Tooth sensitivity (TS) was recorded using a visual analogue scale (VAS) for 16 days. Data were analyzed by one-way analysis of variance (ANOVA) and the Wilcoxon signed-rank test (α=0.05).

RESULTS

All bleaching regimens resulted in a significant increase in WID values (all p<0.05), while no significant differences in WID and ΔWID values were found among the different groups at each time point (all p>0.05). Significant differences in ΔE00 values were observed between T1 and T3 for all groups (all p<0.05), while no significant differences in ΔE00 values were found among the different groups at any time point (all p>0.05). Significantly lower TS values were observed in the HB group than in the OB and HOB groups (p=0.006 and p=0.001, respectively).

CONCLUSIONS

All bleaching regimens resulted in great color improvement, and different regimens led to similar color changes at any of the evaluation time points. The sequence of treatments applying in-office bleaching or at-home bleaching did not affect the bleaching efficacy. The in-office bleaching and combined bleaching regimens yielded a higher intensity of TS than did at-home bleaching.

摘要

目的

本研究旨在比较家庭、诊室和联合漂白方案的临床疗效。

方法

招募了 48 名参与者，并根据漂白方案（n=12）将其随机分为四组：1）使用 10%过氧化脲（Opalescence PF 10%，Ultradent）在家中漂白 14 天（HB）；2）使用 40%过氧化氢（Opalescence BOOST PF 40%，Ultradent）进行两次诊室漂白，间隔一周（OB）；3）一次诊室漂白后在家中漂白七天（OHB）；4）在家中漂白七天后进行一次诊室漂白（HOB）。使用分光光度计（Easyshade，Vita ZahnFabrik）在基线（T0）、第 8 天（T1）、第 15 天（T2）和第 43 天（T3，漂白治疗结束后四周）测量牙齿颜色。使用 CIEDE2000（ΔE00）和牙科白度指数（WID）公式计算颜色数据。使用视觉模拟量表（VAS）记录 16 天的牙齿敏感（TS）。使用单向方差分析（ANOVA）和 Wilcoxon 符号秩检验（α=0.05）进行数据分析。

结果

所有漂白方案均导致 WID 值显著增加（均 p<0.05），但在每个时间点，不同组之间的 WID 和 ΔWID 值均无显著差异（均 p>0.05）。所有组在 T1 和 T3 时的 ΔE00 值均有显著差异（均 p<0.05），但在任何时间点，不同组之间的 ΔE00 值均无显著差异（均 p>0.05）。HB 组的 TS 值明显低于 OB 和 HOB 组（p=0.006 和 p=0.001）。