Hayward J A, Durrani A A, Shelton C J, Lee D C, Chapman D
Biomaterials. 1986 Mar;7(2):126-31. doi: 10.1016/0142-9612(86)90069-4.
A surface layer of phosphorylcholine has been chemically linked with the surface hydroxyl groups present on glass and silica by reaction with mono- and bifunctional reagents. Evidence for the structural integrity of the deposited group was provided by the equimolar association of phosphorus and choline with the reacted surfaces. Modified glass surfaces yielded contact angles which are consistent with those found previously for other models of biological membranes. Covalent modification of the treated surfaces was demonstrated by i.r. spectroscopy via the removal of surface hydroxyl groups. The modified surfaces were thermostable at temperatures up to 375 degrees C for extended periods. The relevance of these results to the generation of new biomaterials is discussed.
通过与单官能和双官能试剂反应，磷酰胆碱的表面层已与玻璃和二氧化硅上存在的表面羟基化学连接。磷和胆碱与反应表面的等摩尔缔合为沉积基团的结构完整性提供了证据。改性玻璃表面产生的接触角与先前在其他生物膜模型中发现的接触角一致。红外光谱通过去除表面羟基证明了处理过的表面发生了共价修饰。改性表面在高达375摄氏度的温度下可长时间保持热稳定性。讨论了这些结果与新型生物材料生成的相关性。
