Durrani A A, Hayward J A, Chapman D
Biomaterials. 1986 Mar;7(2):121-5. doi: 10.1016/0142-9612(86)90068-2.
We have proposed previously that the biocompatibility of biomaterial surfaces might be improved by mimicking the phospholipid components which are present on the external faces of cellular plasma membranes. This approach may have particular relevance to the generation of haemocompatible surfaces, since the distributional asymmetry of phospholipids in the plasma membranes of blood cells is critical to the maintenance of haemostasis. The simplest feature common to the external faces of essentially all the mammalian plasma membranes investigated so far is the high content of the electrically neutral, but zwitterionic, phosphorylcholine. The present communication describes the syntheses of a group of novel reactive species capable of covalently linking phosphorylcholine to a variety of polymer surfaces.
我们之前曾提出，通过模拟存在于细胞质膜外表面的磷脂成分，可能会改善生物材料表面的生物相容性。这种方法可能与生成血液相容性表面特别相关，因为磷脂在血细胞质膜中的分布不对称性对于维持止血至关重要。到目前为止，几乎所有研究过的哺乳动物质膜外表面共有的最简单特征是电中性但为两性离子的磷酸胆碱含量很高。本通讯描述了一组能够将磷酸胆碱共价连接到各种聚合物表面的新型活性物质的合成。
