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一项关于龋齿的遗传及变形链球菌传播性的研究。

A study on genetic and mutans streptococcal transmissibility of dental caries.

作者信息

Chatterjee Shailja, Damle Satyawan G, Iyer Nageshwar

机构信息

Department of Oral and Maxillofacial Pathology, Yamuna Institute of Dental Sciences and Research, Yamuna Nagar, Haryana, India.

Former Vice-chancellor, M. M. (Deemed to be) University, Mullana, Ambala, Haryana, India.

出版信息

J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):604. doi: 10.4103/jomfp.jomfp_201_22. Epub 2022 Dec 22.

DOI:10.4103/jomfp.jomfp_201_22
PMID:37082046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10112085/
Abstract

BACKGROUND

Dental caries is characterized by an interplay between environmental and genetic factors.

AIM

The aim of this study was to analyse the transmissibilities of high caries risk chromosomal loci at 5q 12.1-13.3 and low caries risk chromosomal loci at 13q31.1 and Streptococcus mutans (S. mutans) in family units.

MATERIALS

This prospective cohort study was performed on 56 families grouped into four: (a) Group I: 18 families of children with caries affected primary teeth; (b) Group II: 21 families of children with caries in permanent teeth; (c) Group III: 6 families of children with no caries in primary teeth and (d) Group IV: 12 families of children with no caries in permanent teeth. Blood, saliva and plaque samples were collected from consenting study participants. Isolated DNAs were subjected to polymerase chain reactions using suitable primers. Data collected was analysed with ANOVA and Chi-squared test.

RESULTS

Wide expression of chromosome loci 5q12.1-13.3 was obtained in both blood and saliva samples. For chromosome loci 13q31.1, no expression was found in saliva samples, hence indicating its local absence. For the GtfB expression, transmissibility was common for a single band expressing S. mutans.

CONCLUSION

This study reflects upon newer findings in the field of genetic research on dental caries.

摘要

背景

龋齿是由环境因素和遗传因素相互作用所导致的。

目的

本研究旨在分析5q12.1 - 13.3处高龋齿风险染色体位点、13q31.1处低龋齿风险染色体位点以及变形链球菌在家庭单位中的传递情况。

材料

本前瞻性队列研究对56个家庭进行了分组，分为四组：（a）第一组：18个家庭的儿童乳牙患龋；（b）第二组：21个家庭的儿童恒牙患龋；（c）第三组：6个家庭的儿童乳牙未患龋；（d）第四组：12个家庭的儿童恒牙未患龋。从同意参与研究的对象中采集血液、唾液和菌斑样本。对分离出的DNA使用合适的引物进行聚合酶链反应。收集到的数据采用方差分析和卡方检验进行分析。

结果

在血液和唾液样本中均获得了染色体位点5q12.1 - 13.3的广泛表达。对于染色体位点13q31.1，在唾液样本中未发现表达，因此表明其在局部不存在。对于变形链球菌葡糖基转移酶B（GtfB）的表达，单个表达变形链球菌的条带具有常见的传递性。

结论

本研究反映了龋齿遗传研究领域的新发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/e09fdc1d3894/JOMFP-26-604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/2caaf1a6ad9f/JOMFP-26-604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/93c2f7c956a4/JOMFP-26-604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/e09fdc1d3894/JOMFP-26-604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/2caaf1a6ad9f/JOMFP-26-604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/93c2f7c956a4/JOMFP-26-604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea7a/10112085/e09fdc1d3894/JOMFP-26-604-g003.jpg

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本文引用的文献

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Microorganisms. 2020 Jul 27;8(8):1126. doi: 10.3390/microorganisms8081126.
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A Core Genome Multilocus Sequence Typing Scheme for Streptococcus mutans.变形链球菌核心基因组多位点序列分型方案
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AMELX Gene Association with Dental Caries in Iranian Adults.AMELX基因与伊朗成年人龋齿的关联
Int J Mol Cell Med. 2019 Fall;8(4):294-300. doi: 10.22088/IJMCM.BUMS.8.4.294.
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Activity of Carbonic Anhydrase VI is Higher in Dental Biofilm of Children with Caries.碳酸酐酶 VI 在龋齿儿童的牙菌斑中的活性更高。
Int J Mol Sci. 2019 May 30;20(11):2673. doi: 10.3390/ijms20112673.
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Medical Model in Caries Management.龋病管理中的医学模式。
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Dental Caries Experience, Dental Anomalies, and Morphometric Analysis of Canine among Monozygotic and Dizygotic Twins.单卵双胞胎和双卵双胞胎中龋齿经历、牙齿异常及犬齿形态测量分析
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Prevalence of Dental Caries Among Primary School Children of India - A Cross-Sectional Study.印度小学生龋齿患病率——一项横断面研究
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