Division of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
Pediatr Pulmonol. 2023 Jul;58(7):2042-2049. doi: 10.1002/ppul.26429. Epub 2023 Apr 21.
Radon may have a role in obstructive lung disease outside its known carcinogenicity. Little is known about radon's effects on asthma morbidity.
To determine the effect of radon on fractional exhaled nitric oxide (F NO), asthma symptom-days, and lung function in inner-city asthmatic school children.
Two hundred ninety-nine school-aged asthmatic children enrolled in the School Inner-City Asthma Study (SICAS-1) were followed. One and two-month averaged radon was assessed using a spatiotemporal model predicting zip code-specific monthly exposures. F NO and spirometry were measured twice during the academic year. Asthma symptoms were assessed four times during the academic year. The interaction between indoor radon exposure (Bq/m ) and seasonality predicting log-transformed F NO, forced expiratory volume in 1 s (FEV ) % predicted, forced vital capacity (FVC) % predicted, FEV /FVC, and asthma symptom-days was evaluated.
Participants with high radon exposure had greater change in F NO from warm to cold periods compared to low radon exposure (interaction p = 0.0013). Participants with >50th percentile radon exposure experience significant F NO increase from warm to cold weather ( = 0.29 [95% confidence interval [CI]: 0.04-0.54], p = 0.0240). We report a positive association between radon 1-month moving average (incidence rate ratio [IRR] = 1.01, p = 0.0273) and 2-month moving average (IRR = 1.01, p = 0.0286) with maximum asthma symptom-days (n = 299, obs = 1167).
In asthmatic children, radon may be associated with increased asthma morbidity, suggesting radon may be a modifiable environmental risk factor for airway inflammation.
氡除了已知的致癌性外，可能在阻塞性肺部疾病中发挥作用。然而，人们对氡对哮喘发病率的影响知之甚少。
确定氡对城市内哮喘学童的呼出气一氧化氮分数（F NO）、哮喘症状天数和肺功能的影响。
对参加城市内哮喘研究（SICAS-1）的 299 名学龄哮喘儿童进行了随访。使用时空模型预测邮政编码特定的每月暴露情况，评估 1 个月和 2 个月的平均氡浓度。在学年期间测量两次 F NO 和肺活量测定。在学年期间四次评估哮喘症状。评估室内氡暴露（Bq/m ）与季节变化对 F NO、1 秒用力呼气量（FEV ）预测值、用力肺活量（FVC）预测值、FEV/FVC 和哮喘症状天数的对数转换值的交互作用。
高氡暴露组的 F NO 从温暖期到寒冷期的变化大于低氡暴露组（交互作用 p = 0.0013）。暴露于>50 百分位氡的参与者从温暖天气到寒冷天气时 F NO 显著增加（ = 0.29 [95%置信区间：0.04-0.54]， p = 0.0240）。我们报告了氡 1 个月移动平均值（发病率比 [IRR] = 1.01， p = 0.0273）和 2 个月移动平均值（IRR = 1.01， p = 0.0286）与最大哮喘症状天数之间存在正相关（n = 299，观测值 = 1167）。
在哮喘儿童中，氡可能与哮喘发病率增加有关，这表明氡可能是气道炎症的一个可改变的环境风险因素。
