Lauritzen M, Diemer N H
Brain Res. 1986 Apr 9;370(2):405-8. doi: 10.1016/0006-8993(86)90504-4.
The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.
本研究旨在评估大鼠大脑皮质扩散性抑制（CSD）后持续的低灌注是否伴随着局部皮质葡萄糖消耗（rCGU）的改变。在单次CSD发作后15 - 60分钟，使用2-脱氧-[14C]葡萄糖和放射自显影法测量rCGU。与对侧和假手术处理的大鼠相比，CSD侵袭的皮质区域的rCGU没有差异。结果提示CSD后代谢-血流偶联受损。
