Gjedde A, Hansen A J, Quistorff B
J Neurochem. 1981 Oct;37(4):807-12. doi: 10.1111/j.1471-4159.1981.tb04465.x.
Spreading depression in rat brain cortex is associated with a twofold increase of cerebral blood flow. It is not known whether this increase is coupled to increases of cerebral metabolic rate and glucose transport from blood to brain. During the passage of a single spreading depression, we measured blood-brain glucose transport and glucose metabolism in rat cerebral cortex by single intravenous injection of tracer glucose. Blood flow and tissue content of glucose were measure as well. Reduction of tissue glucose and the consequent increase of net transfer of glucose from blood to brain were consistent with a threefold increase of the consumption of glucose before the increase of blood flow. There was no increase of unidirectional blood-brain transfer.
大鼠大脑皮层中的扩散性抑制与脑血流量增加两倍有关。目前尚不清楚这种增加是否与脑代谢率的增加以及葡萄糖从血液到大脑的转运增加相关。在单次扩散性抑制过程中，我们通过单次静脉注射示踪葡萄糖来测量大鼠大脑皮层中的血脑葡萄糖转运和葡萄糖代谢。同时也测量了血流量和葡萄糖的组织含量。组织葡萄糖的减少以及随之而来的葡萄糖从血液到大脑的净转运增加与血流量增加之前葡萄糖消耗增加三倍是一致的。单向血脑转运没有增加。
