State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China.
Institute of Developmental Psychology, Beijing Normal University, 100875, Beijing, China.
Nat Commun. 2023 Apr 21;14(1):2299. doi: 10.1038/s41467-023-38046-y.
The misinformation effect occurs when people's memory of an event is altered by subsequent inaccurate information. No study has systematically tested theories about the dynamics of human hippocampal representations during the three stages of misinformation-induced false memory. This study replicates behavioral results of the misinformation effect, and investigates the cross-stage pattern similarity in the hippocampus and cortex using functional magnetic resonance imaging. Results show item-specific hippocampal pattern similarity between original-event and post-event stages. During the memory-test stage, hippocampal representations of original information are weakened for true memory, whereas hippocampal representations of misinformation compete with original information to create false memory. When false memory occurs, this conflict is resolved by the lateral prefrontal cortex. Individuals' memory traces of post-event information in the hippocampus predict false memory, whereas original information in the lateral parietal cortex predicts true memory. These findings support the multiple-trace model, and emphasize the reconstructive nature of human memory.
当人们对一个事件的记忆被后续不准确的信息改变时，就会发生错误信息效应。没有研究系统地测试了关于人类海马体在错误信息诱导的虚假记忆三个阶段中的动态的理论。本研究复制了错误信息效应的行为结果，并使用功能磁共振成像研究了海马体和皮层在跨阶段的模式相似性。结果表明，在原始事件和事件后阶段之间存在特定于项目的海马体模式相似性。在记忆测试阶段，原始信息的海马体表示对于真实记忆减弱，而错误信息的海马体表示与原始信息竞争以产生虚假记忆。当发生虚假记忆时，这种冲突由外侧前额叶皮层解决。个体在海马体中对事件后信息的记忆痕迹预测虚假记忆，而外侧顶叶皮层中的原始信息预测真实记忆。这些发现支持了多轨迹模型，并强调了人类记忆的重构性质。
