Liggins Institute, University of Auckland, Auckland, New Zealand.
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, UK.
Eur J Nutr. 2023 Aug;62(5):2257-2267. doi: 10.1007/s00394-023-03151-7. Epub 2023 Apr 21.
Metabolomic dysregulation following a meal in overweight individuals with the Metabolic Syndrome (MetS) involves multiple pathways of nutrient storage and oxidation.
The aim of the current study was to perform an acute cross-over intervention to examine the interactive actions of meal glycaemic load (GL) on the dynamic responses of the plasma metabolome in overweight females.
Postmenopausal women [63 ± 1.23y; Healthy (n = 20) and MetS (n = 20)] ingested two differing high-carbohydrate test meals (73 g carbohydrate; 51% energy) composed of either low glycemic index (LGI) or high (HGI) foods in a randomised sequence. Plasma metabolome was analysed using liquid chromatography-mass spectrometry (LC-MS).
In the overweight women with MetS, there were suppressed postprandial responses for several amino acids (AAs), including phenylalanine, leucine, valine, and tryptophan, p < 0.05), irrespective of the meal type. Meal GL exerted a limited impact on the overall metabolomic response, although the postprandial levels of alanine were higher with the low GL meal and uric acid was greater following the high GL meal (p < 0.05).
MetS participants exhibited reduced differences in the concentrations of a small set of AAs and a limited group of metabolites implicated in energy metabolism following the meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome. This study suggests that the GL of a meal is not a major determinant of postprandial response, with a greater impact exerted by the metabolic health of the individual. Trial registration Australia New Zealand Clinical Trials Registry: ACTRN12615001108505 (21/10/2015).
超重的代谢综合征（Metabolic Syndrome，MetS）患者在餐后会出现代谢失调，涉及到多种营养储存和氧化途径。
本研究旨在进行急性交叉干预，以检查餐后血糖负荷（glycaemic load，GL）对超重女性血浆代谢组动态反应的交互作用。
绝经后女性[63±1.23 岁；健康（n=20）和 MetS（n=20）]随机顺序摄入两种不同的高碳水化合物测试餐（73 克碳水化合物；51%能量），由低升糖指数（low glycemic index，LGI）或高升糖指数（high glycemic index，HGI）食物组成。采用液相色谱-质谱联用（liquid chromatography-mass spectrometry，LC-MS）分析血浆代谢组。
在超重的 MetS 女性中，几种氨基酸（amino acids，AAs）的餐后反应受到抑制，包括苯丙氨酸、亮氨酸、缬氨酸和色氨酸，p<0.05），与餐型无关。尽管低 GL 餐餐后丙氨酸水平较高，高 GL 餐餐后尿酸水平较高（p<0.05），但 GL 对整体代谢组反应的影响有限。
MetS 参与者在餐后表现出浓度差异较小的一组 AA 和一组有限的与能量代谢相关的代谢物。然而，餐 GL 的操纵对餐后代谢组的影响很小。这项研究表明，餐的 GL 不是餐后反应的主要决定因素，个体的代谢健康状况影响更大。
澳大利亚新西兰临床试验注册中心：ACTRN12615001108505（2015 年 10 月 21 日）。
