Center for Women and Children Health Research, Wuhan University School of Nursing, Wuhan University, 169 Donghu Road, Wuhan 430071, China.
Emory University Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road, Atlanta, GA 30322, USA.
J Affect Disord. 2023 Jul 15;333:342-352. doi: 10.1016/j.jad.2023.04.073. Epub 2023 Apr 21.
Temperament has been shown to be associated with the change of gut microbiome. There were no longitudinal studies to explore the role of gut microbiome changes in the development of temperament in toddlers.
This study used longitudinal cohort to investigate the associations between changes in gut microbiome and temperament in toddlers in the first two years of life. Linear regression analysis and microbiome multivariate association with linear models were used to investigate the associations between the gut microbiome and toddlers' temperament.
In total, 41 toddlers were analyzed. This study found both Shannon and Chao-1 indices at birth were negatively correlated with the sadness dimension; the higher the Shannon and Chao-1 indices at 6 months, the lower the surgency/extraversion dimension scores; the higher the Shannon and Chao-1 indices at 2 years of ages, the lower the cuddliness dimension scores. After adjusting for covariates, beta diversity at birth was strongly associated with the negative affectivity dimension; beta diversity at 1 year of age was strongly associated with the activity level dimension; and beta diversity at 2 years of age was strongly associated with the discomfort and soothability dimension. Compared to Bifidobacterium cluster, this study also found Bacteroides cluster was associated with lower negative affectivity and its sub-dimensions frustration and sadness scores in toddlers.
Generalizability of the results remains to be determined.
Results of this study confirmed the associations between changes in the gut microbiome diversity and composition in the first two years of life and toddlers' temperament.
气质已被证明与肠道微生物群的变化有关。目前还没有纵向研究来探索肠道微生物群变化在幼儿气质发展中的作用。
本研究采用纵向队列研究来调查幼儿在生命的头两年中肠道微生物群变化与气质之间的关系。线性回归分析和微生物组多元线性模型关联分析用于研究肠道微生物群与幼儿气质之间的关系。
共分析了 41 名幼儿。本研究发现出生时的 Shannon 和 Chao-1 指数与悲伤维度呈负相关；6 个月时 Shannon 和 Chao-1 指数越高，活力/外向性维度得分越低；2 岁时 Shannon 和 Chao-1 指数越高，温顺维度得分越低。在调整协变量后，出生时的β多样性与负性情感维度强烈相关；1 岁时的β多样性与活动水平维度强烈相关；2 岁时的β多样性与不适和安抚维度强烈相关。与双歧杆菌属簇相比，本研究还发现拟杆菌属簇与幼儿的负性情感及其子维度挫折感和悲伤感得分较低有关。
结果的普遍性仍有待确定。
本研究结果证实了生命头两年肠道微生物群多样性和组成的变化与幼儿气质之间的关系。
