Ozturk Derya, Melekoglu Adem, Altinbilek Ertugrul, Calik Mustafa, Kosem Arzu, Kilci Hakan, Misirlioglu Naile Fevziye, Uzun Hafize
Sisli Hamidiye Etfal Education and Research Hospital, Department of Emergency, İstanbul, Turkey.
Gaziosmanpasa Education and Research Hospital, Department of Emergency, İstanbul, Turkey.
Int J Gen Med. 2023 Apr 17;16:1355-1362. doi: 10.2147/IJGM.S403564. eCollection 2023.
An acute ST-elevation myocardial infarction (STEMI) is a serious cardiovascular condition with a high risk of morbidity and mortality. Irisin is adipomyokine that is associated with various health conditions. In post-STEMI, elevated serum irisin levels are associated with more adverse cardiovascular events.
The purpose of this study was to investigate associations between the serum irisin levels and acute MI (AMI) and whether irisin may be a useful biomarker for severity of AMI in patients with STEMI. Possible correlations between serum irisin and cardiac troponin-I (cTi) levels were investigated.
A total of 90 subjects (46 control subjects and 44 STEMI patients) were included in the study. Besides demographic data, presence of diabetes mellitus and hypertension, electrocardiography (ECG) findings, blood biochemistry, cardiac biomarkers (cTi) and serum irisin levels were examined.
Significantly lower heart rate (HR) and significantly higher ST-elevation and QTc interval were detected in ECG recordings in STEMI patients (p < 0.05). Serum irisin levels were significantly lower in STEMI patients compared to the control subjects (p < 0.001). The decrease in the serum irisin levels was significantly correlated with the increase in cTi levels, as well as increased QTc (p < 0.05). The sensitivity and specificity of irisin were found to be 93% and 78%, respectively.
Decreased irisin levels were found to be highly predictive in STEMI. In patients with STEMI, the serum irisin levels were associated with cTi levels and QTc, suggesting that irisin is a promising biomarker for AMI cases.
急性ST段抬高型心肌梗死（STEMI）是一种严重的心血管疾病，具有较高的发病和死亡风险。鸢尾素是一种与多种健康状况相关的脂肪肌动蛋白。在STEMI后，血清鸢尾素水平升高与更多不良心血管事件相关。
本研究旨在探讨血清鸢尾素水平与急性心肌梗死（AMI）之间的关联，以及鸢尾素是否可能是STEMI患者AMI严重程度的有用生物标志物。研究了血清鸢尾素与心肌肌钙蛋白I（cTi）水平之间的可能相关性。
本研究共纳入90名受试者（46名对照受试者和44名STEMI患者）。除人口统计学数据、糖尿病和高血压的存在情况外，还检查了心电图（ECG）结果、血液生化、心脏生物标志物（cTi）和血清鸢尾素水平。
STEMI患者的心电图记录中检测到心率（HR）显著降低，ST段抬高和QTc间期显著升高（p < 0.05）。与对照受试者相比，STEMI患者的血清鸢尾素水平显著降低（p < 0.001）。血清鸢尾素水平的降低与cTi水平的升高以及QTc的增加显著相关（p < 0.05）。发现鸢尾素的敏感性和特异性分别为93%和78%。
发现鸢尾素水平降低在STEMI中具有高度预测性。在STEMI患者中，血清鸢尾素水平与cTi水平和QTc相关，表明鸢尾素是AMI病例的一种有前景的生物标志物。
