Thomas J C, Wiltse L L, Widell E H, Spencer C W, Zindrick M R, Field B T
Clin Orthop Relat Res. 1986 May(206):61-6.
An 11.8-year median follow-up evaluation of 42 "ideal" patients who had chemonucleolysis was obtained by examination, questionnaire, and roentgenograms. The excellent and good rating of this group was 81%, as compared to the total of 135 patients previously evaluated at 42 months and showing 85.2%. No complications were noted. Disc space rewidening, after initial narrowing, was observed in eight patients and 26% of all discs injected. While all who showed rewidening had excellent results, widening was not necessary to achieve an excellent rating. Marked narrowing and sclerosis of intervertebral margins were seen in many excellent and good clinical results. Chemonucleolysis represents a viable option as definitive treatment for a herniated nucleus pulposus in carefully selected patients.
通过检查、问卷调查和X光片对42例接受化学髓核溶解术的“理想”患者进行了为期11.8年的中位随访评估。该组的优良率为81%，而之前在42个月时评估的135例患者的总优良率为85.2%。未发现并发症。8例患者出现椎间盘间隙在最初变窄后重新增宽，占所有注射椎间盘的26%。虽然所有出现间隙增宽的患者都取得了优异的效果，但间隙增宽并非获得优异评级的必要条件。在许多临床效果优良的病例中都可见到椎间边缘明显变窄和硬化。对于精心挑选的患者，化学髓核溶解术是治疗椎间盘突出症的一种可行的确定性治疗选择。
