Khan Madiha, Park Lily, Skopit Stanley
Department of Dermatology, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Department of Dermatology, Larkin Community Hospital, Miami, USA.
Cureus. 2023 Mar 21;15(3):e36481. doi: 10.7759/cureus.36481. eCollection 2023 Mar.
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune condition with various triggers. Because of the lack of randomized controlled trials on LABD treatment, management options are mostly anecdotal. This paper provides a comprehensive review of treatment options from a literature review of reported treatments to arm clinicians with a guideline for the management of LABD in both pediatric and adult patients as well as those recalcitrant to first-line therapy (dapsone and steroids). We additionally illustrate an algorithm to use for the management of LABD to aid clinicians when faced with unique patient circumstances.
线状免疫球蛋白A（IgA）大疱性皮肤病（LABD）是一种由多种诱因引起的自身免疫性疾病。由于缺乏关于LABD治疗的随机对照试验，治疗方案大多基于经验。本文通过对已报道治疗方法的文献综述，全面回顾了治疗方案，为儿科和成年患者以及一线治疗（氨苯砜和类固醇）难治性LABD患者的管理提供指导，以帮助临床医生。此外，我们还阐述了一种用于LABD管理的算法，以便临床医生在面对特殊患者情况时提供帮助。
