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基于气相色谱-质谱联用技术的苹果醋代谢物谱分析、抗氧化及抗尿路结石特性

GC-MS based metabolite profiling, antioxidant and antiurolithiatic properties of apple cider vinegar.

作者信息

Singh Ankul S, Singh Anuragh, Vellapandian Chitra, Ramaswamy Radhika, Thirumal Margesan

机构信息

Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.

Department of Pharmacognosy, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.

出版信息

Future Sci OA. 2023 Apr 11;9(4):FSO855. doi: 10.2144/fsoa-2023-0035. eCollection 2023 Apr.

DOI:10.2144/fsoa-2023-0035
PMID:37090488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10116371/
Abstract

AIM

To perform analysis of antioxidant and antiurolithiasis to carry out GC-MS-based metabolite profile.

MATERIALS & METHODS: The effect of apple cider vinegar (ACV) , antioxidant and GC-MS analysis was evaluated. The antioxidant studies were performed. techniques included nucleation, aggregation and growth assay.

RESULTS & CONCLUSION: The presence of polyphenols, flavonoids, alkaloids and carbohydrates was shown. Concentrations from 5-30 μg/ml could dissolve calcium oxalate (p < 0.05) . The IC value of ACV in DPPH was found to be around 7 μg/ml and the IC value of the ACV in ABTS assay was around 9 μg/ml. Different phytocompounds were obtained from GC-MS analysis. ACV can be consumed to prevent kidney stones which seems helpful to the current therapy.

摘要

目的

通过基于气相色谱 - 质谱联用的代谢物谱分析来进行抗氧化和抗尿路结石分析。

材料与方法

评估了苹果醋（ACV）的效果、抗氧化作用以及气相色谱 - 质谱联用分析。进行了抗氧化研究。技术包括成核、聚集和生长测定。

结果与结论

结果显示存在多酚、黄酮类、生物碱和碳水化合物。浓度为5 - 30μg/ml时可溶解草酸钙（p < 0.05）。苹果醋在二苯基苦味酰基自由基（DPPH）测定中的半数抑制浓度（IC）值约为7μg/ml，在2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）测定中的IC值约为9μg/ml。通过气相色谱 - 质谱联用分析获得了不同的植物化合物。饮用苹果醋可预防肾结石，这似乎对当前治疗有帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/24595e32a330/fsoa-09-855-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/2d5a61288554/fsoa-09-855-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/7674d1e88885/fsoa-09-855-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/4772eec9e313/fsoa-09-855-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/2c705f955034/fsoa-09-855-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/24595e32a330/fsoa-09-855-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/2d5a61288554/fsoa-09-855-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/7674d1e88885/fsoa-09-855-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/4772eec9e313/fsoa-09-855-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/2c705f955034/fsoa-09-855-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b4/10116371/24595e32a330/fsoa-09-855-g5.jpg

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