Shamloo Shirin, Defensor Erwin, Ciari Peter, Ogawa Gaku, Vidano Laura, Lin Jennifer S, Fortkort John A, Shamloo Mehrdad, Barron Annelise E
Department of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Front Neurosci. 2023 Apr 6;17:1150156. doi: 10.3389/fnins.2023.1150156. eCollection 2023.
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
迫切需要能够预防或限制神经炎症过程并防止神经元变性的治疗方法。光生物调节（PBM），即特定波长光的治疗性应用，是一种已被证明具有抗炎作用的安全方法。当前的研究旨在评估PBM对脂多糖（LPS）诱导的小鼠外周和中枢炎症的影响，以评估其作为抗炎治疗的潜力。在LPS攻击前10天，每天用红色/近红外光（RL）或带有40赫兹伽马频率闪烁的RL对小鼠进行30分钟的治疗，结果显示在大脑和全身均有抗炎作用。PBM下调了与炎性小体激活相关的关键促炎细胞因子IL-1β和IL-18的LPS诱导表达，并上调了抗炎细胞因子IL-10。RL具有强大的抗炎作用，而添加伽马闪烁增强了这些作用。总体而言，这些结果证明了PBM作为一种通过调节细胞因子表达发挥作用的抗炎治疗方法的潜力。
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