Yamazaki Kaori, Maejima Maho, Saeki Hidehisa, Osada Shin-Ichi
Department of Dermatology, Nippon Medical School Tama Nagayama Hospital, Tokyo 206-8512, Japan.
Department of Dermatology, Nippon Medical School, Tokyo 113-8603, Japan.
Dermatopathology (Basel). 2023 Mar 28;10(2):128-135. doi: 10.3390/dermatopathology10020019.
Basal cell carcinoma (BCC) is the most common cutaneous malignancy, usually occurring in sun-exposed areas. Although BCC in the scrotal region is uncommon, it carries a higher risk of metastasis than BCC at other sites. Here, we report two cases of BCC that developed in the scrotal region: Case 1 presented as a superficial nodule and Case 2 as a subcutaneous nodule. Histopathologically, both tumors lacked continuity with the surface epidermis and formed an intradermal nodule. In Case 1, BCC occurred for the first time and presumably developed . Case 2 underwent excision of a scrotal BCC 5 years previously, and the histopathological diagnosis at that time was nodular BCC. However, when the original specimen was re-examined, it was determined that, although the tumor had been completely resected, part of the lesion had moved away from the nodular area to represent a micronodular phenotype, an aggressive BCC subtype. We hypothesized that partial evolution from a nodular to a micronodular phenotype may have contributed to the recurrence of BCC in Case 2.
基底细胞癌（BCC）是最常见的皮肤恶性肿瘤，通常发生在阳光暴露部位。虽然阴囊区域的基底细胞癌并不常见，但与其他部位的基底细胞癌相比，其转移风险更高。在此，我们报告两例发生在阴囊区域的基底细胞癌病例：病例1表现为浅表结节，病例2表现为皮下结节。组织病理学上，这两个肿瘤均与表面表皮无连续性，形成真皮内结节。在病例1中，基底细胞癌为首次发生，推测其发展过程为……病例2在5年前接受了阴囊基底细胞癌切除术，当时的组织病理学诊断为结节性基底细胞癌。然而，当对原始标本进行重新检查时发现，尽管肿瘤已被完全切除，但部分病变已从结节区域转移，呈现微结节表型，这是一种侵袭性基底细胞癌亚型。我们推测，从结节性表型到微结节性表型的部分演变可能是病例2中基底细胞癌复发的原因。
