Squires Matthew, Tao Xiaohui, Elangovan Soman, Gururajan Raj, Zhou Xujuan, Acharya U Rajendra, Li Yuefeng
School of Mathematics, Physics and Computing, University of Southern Queensland, Toowoomba, QLD, Australia.
Belmont Private Hospital, QLD, Brisbane, Australia.
Brain Inform. 2023 Apr 24;10(1):10. doi: 10.1186/s40708-023-00188-6.
Informatics paradigms for brain and mental health research have seen significant advances in recent years. These developments can largely be attributed to the emergence of new technologies such as machine learning, deep learning, and artificial intelligence. Data-driven methods have the potential to support mental health care by providing more precise and personalised approaches to detection, diagnosis, and treatment of depression. In particular, precision psychiatry is an emerging field that utilises advanced computational techniques to achieve a more individualised approach to mental health care. This survey provides an overview of the ways in which artificial intelligence is currently being used to support precision psychiatry. Advanced algorithms are being used to support all phases of the treatment cycle. These systems have the potential to identify individuals suffering from mental health conditions, allowing them to receive the care they need and tailor treatments to individual patients who are mostly to benefit. Additionally, unsupervised learning techniques are breaking down existing discrete diagnostic categories and highlighting the vast disease heterogeneity observed within depression diagnoses. Artificial intelligence also provides the opportunity to shift towards evidence-based treatment prescription, moving away from existing methods based on group averages. However, our analysis suggests there are several limitations currently inhibiting the progress of data-driven paradigms in care. Significantly, none of the surveyed articles demonstrate empirically improved patient outcomes over existing methods. Furthermore, greater consideration needs to be given to uncertainty quantification, model validation, constructing interdisciplinary teams of researchers, improved access to diverse data and standardised definitions within the field. Empirical validation of computer algorithms via randomised control trials which demonstrate measurable improvement to patient outcomes are the next step in progressing models to clinical implementation.
近年来,用于脑与心理健康研究的信息学范式取得了显著进展。这些进展很大程度上可归因于机器学习、深度学习和人工智能等新技术的出现。数据驱动方法有潜力通过提供更精确和个性化的方法来支持心理健康护理,用于抑郁症的检测、诊断和治疗。特别是,精准精神病学是一个新兴领域,它利用先进的计算技术来实现更个性化的心理健康护理方法。本综述概述了人工智能目前用于支持精准精神病学的方式。先进的算法正被用于支持治疗周期的各个阶段。这些系统有潜力识别患有心理健康问题的个体,使他们能够得到所需的护理,并为最有可能受益的个体患者量身定制治疗方案。此外,无监督学习技术正在打破现有的离散诊断类别,并突出了在抑郁症诊断中观察到的巨大疾病异质性。人工智能还提供了转向循证治疗处方的机会,摆脱现有的基于群体平均值的方法。然而,我们的分析表明,目前有几个限制因素阻碍了数据驱动范式在护理领域的进展。值得注意的是,在所调查的文章中,没有一篇实证证明比现有方法能改善患者的治疗效果。此外,需要更多地考虑不确定性量化、模型验证、组建跨学科研究团队、改善获取多样化数据的机会以及该领域内的标准化定义。通过随机对照试验对计算机算法进行实证验证,证明对患者治疗效果有可衡量的改善,这是将模型推进到临床应用的下一步。