School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, GST road, Vandalur, Chennai-600048, Tamil Nadu, India.
Department of Botany, Government Arts and Science College, Harur, Tamil Nadu, India.
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2711-2721. doi: 10.31557/APJCP.2024.25.8.2711.
According to an international survey, the cancer occurrence in the breast is the foremost in women. Surgery and chemotherapy remain the definitive treatment for the breast cancer. The bio-green methods of synthesizing silver nanoparticles are cost-effective and eco-friendly when parallel to physical and chemical methods. In addition, they effectively control pathogenic microorganisms. Former research studies reveal that kalijiri a common name for Centratherum anthelminticum is used as a traditional medicine for various ailments including anti-bacterial, anti-fungal, antidiabetic and anticancer. Our present research study focal points on the green synthesis of silver nanoparticles using aqueous seed extract of Centratherum anthelminticum and the evaluation of their antioxidant and cytotoxic activity.
An aqueous extract of seeds from Centratherum anthelminticum was prepared by boiling it with distilled water. The silver nanoparticles were synthesized from the seeds of Centratherum anthelminticum and characterized by various methods such as UV-Visible spectroscopy, FT-IR, Transmission electron microscopy, DLS and X-ray diffraction to confirm the formation of nanoparticles.
The cytotoxic analysis of MDA-MB-231 cells was tested with the synthesized silver nanoparticles complex. The observed result was IC50 of 35.06±1.2 and it was not shown any toxicity to the non-cancerous cell line.
In a nutshell, the synthesized silver nanoparticles from the seeds of Centratherum anthelminticum may be used for the treatment of breast cancer. Further studies are warranted to furnish the mechanism of action.
根据一项国际调查，乳腺癌在女性中的发病率最高。手术和化疗仍然是乳腺癌的主要治疗方法。与物理和化学方法相比，生物绿色方法合成的银纳米粒子具有成本效益和环保性。此外，它们还能有效控制致病微生物。以前的研究表明，Kalijiri（即 Centratherum anthelminticum 的俗称）作为一种传统药物，可用于治疗各种疾病，包括抗菌、抗真菌、抗糖尿病和抗癌。我们目前的研究重点是使用 Centratherum anthelminticum 的水种子提取物来绿色合成银纳米粒子，并评估其抗氧化和细胞毒性活性。
用蒸馏水煮沸 Centratherum anthelminticum 的种子来制备种子的水提取物。用 Centratherum anthelminticum 的种子合成银纳米粒子，并通过各种方法进行表征，如紫外可见光谱、傅里叶变换红外光谱、透射电子显微镜、动态光散射和 X 射线衍射，以确认纳米粒子的形成。
用合成的银纳米粒子复合物对 MDA-MB-231 细胞进行细胞毒性分析。观察到的 IC50 为 35.06±1.2，对非癌细胞系没有显示出任何毒性。
简而言之，从 Centratherum anthelminticum 种子中合成的银纳米粒子可用于治疗乳腺癌。需要进一步的研究来提供作用机制。
